DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and shk1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_596626.1	Gene:	shk1 / 2539997	PomBaseID:	SPBC1604.14c	Length:	658	Species:	Schizosaccharomyces pombe

Alignment Length:	767	Identity:	169/767 - (22%)
Similarity:	286/767 - (37%)	Gaps:	200/767 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 IQPKKEQIRIEINQTAPQ----NSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHIQ 663
            :||:|:         ||.    ..|.||.........|.||  .|.|:||      .:|.:....
pombe     6 LQPRKK---------APNGYGITPIVAHKTGEPVRYEVEDD--LRKLKPS------RTAPKPPAI 53

  Fly   664 TRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNH 728
            ...||:|..|....|.|.::..|.|..:......|:...|.::|::.|
pombe    54 NTNLAEDTFSGFPLSQSRTTVSRVSLGSRQHSSSSIRKLQTNVSDVRS----------------- 101

  Fly   729 ILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSAS--QSTIITSTITTT 791
              .:|::.|:: ..::..||.|...|...||.         |||..:.|||  :||:|:|.....
pombe   102 --YDERNQKKS-AFENFVSSMSSFLTGGGSSP---------TSSYGSGSASPRKSTVISSPFDPK 154

  Fly   792 ITTTT---------TTTPSKENSRLKF----KVPKIQKKSKAI---------------------- 821
            ..|..         |..|::..:.||.    |..::|.....:
pombe   155 HVTHVGFNYDTGEFTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQSKKYLEEGAKPPFP 219

  Fly   822 RNTFRSKLLNFQLKRS----KPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPA 882
            |.:....||:.....|    :|....:...|::||:..        ...||.|::.      |..
pombe   220 RESTEKPLLSVSALSSSSHLQPTSATSSSSRLYPSRPA--------PTPPASSSSS------PLL 270

  Fly   883 GQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASI 947
            ..:.||.:...:..:..|..||                    .::|:::  :.|.   |.|....
pombe   271 SSQTVKTTTSNASRQPSPLVSS--------------------KSTDNII--RSHS---PVLLTPQ 310

  Fly   948 SLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGE 1012
            :|||:...:       :.|        ||...:..|.....:...:....
pombe   311 TLSTSETKH-------IRP--------NNSTPYQRRAETSTKPKAVATPQ--------------- 345

  Fly  1013 GNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLER----IGRGN 1073
               :.|.|....:|:....|..::..|..|     .:.:|..:      :..||.|    ||:|.
pombe   346 ---KVEAPSAPRLQKRAPRQQSNDSAVLAK-----LQSICNPK------NPTLLYRNFVKIGQGA 396

  Fly  1074 FGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFL-QEGRILKQYDHPNIVKLIGICVQKQPIMIV 1137
            .||||.|:...|.|.||:|  :|.:..:.|::|: .|..::|.:.|.|||..|.....|..:.:|
pombe   397 SGDVYSARQVGTNLSVAIK--KMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMV 459

  Fly  1138 MELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKIS 1202
            ||.:.||||...:..|:  |:..|...:|::...|:::|.....:|||:.:.|.|:.|:..:|::
pombe   460 MEYMRGGSLTEVVTNNT--LSEGQIAAICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLT 522

  Fly  1203 DFGMSREEEEYIVSDGMKQIPV----KWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSG 1263
            |||...:    |.|:..|:..:    .|.|||.:...:|....||||.||:..|:. :|:.||..
pombe   523 DFGFCAQ----IDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMV-EGEPPYLN 582

  Fly  1264 MTNSRARERIDTGYRMPTPK-STPEEM----YRLMLQCWAADAESRPHFDEI 1310
            ....||...|.|   :.||| |.||.:    :..:.:....:.:.||...|:
pombe   583 ENPLRALYLIAT---IGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGEL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	8/85 (9%)
		TyrKc	1063..1311	CDD:197581	81/262 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	79/258 (31%)
shk1	NP_596626.1	PBD	146..200	CDD:279166	9/53 (17%)
		STKc_PAK	385..638	CDD:270789	80/259 (31%)
		S_TKc	391..637	CDD:214567	78/253 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000