DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and FYN

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001357458.1	Gene:	FYN / 2534	HGNCID:	4037	Length:	537	Species:	Homo sapiens

Alignment Length:	392	Identity:	135/392 - (34%)
Similarity:	209/392 - (53%)	Gaps:	51/392 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   958 EEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSVCWN----GH-KHFIVQTTGEG 1013
            |||:.|.|.|::..|.|    |..|.||:||:...:.:..:....|:    .| ||:.::....|
Human   147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNG 211

  Fly  1014 NFRF-EGPPFASIQELIMH--------------QYHSELP----VTVKSGAILRRPVCRERWELS 1059
            .:.. ....|.::|:|:.|              ..|..:|    ::||:         ::.||:.
Human   212 GYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKT---------KDVWEIP 267

  Fly  1060 NDDVVLLERIGRGNFGDVYKAKLK-STKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIV 1122
            .:.:.|::|:|.|.||:|:..... :||  ||:||.:. |:..|   .||:|.:|:|:..|..:|
Human   268 RESLQLIKRLGNGQFGEVWMGTWNGNTK--VAIKTLKPGTMSPE---SFLEEAQIMKKLKHDKLV 327

  Fly  1123 KLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHRD 1185
            :|..: |.::||.||.|.:..||||.:| |:..|  |.....:.|....||||.|:|..|.||||
Human   328 QLYAV-VSEEPIYIVTEYMNKGSLLDFL-KDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRD 390

  Fly  1186 LAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGI 1248
            |.:.|.||......||:|||::|  |:.||....|.| .|:|||||||..:|::|...||||:||
Human   391 LRSANILVGNGLICKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGI 454

  Fly  1249 LMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNV 1313
            |:.|:.:||..||.||.|....|:::.|||||.|:..|..::.||:.||..|.|.||.|:.:.:.
Human   455 LLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSF 519

  Fly  1314 VD 1315
            ::
Human   520 LE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/108 (23%)
		TyrKc	1063..1311	CDD:197581	106/253 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/253 (42%)
FYN	NP_001357458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	23/97 (24%)
		PTKc_Fyn	261..534	CDD:270655	108/269 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910