DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Jak3

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_036987.2	Gene:	Jak3 / 25326	RGDID:	2940	Length:	1100	Species:	Rattus norvegicus

Alignment Length:	288	Identity:	95/288 - (32%)
Similarity:	148/288 - (51%)	Gaps:	33/288 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1061 DDVVLLER-------IGRGNFGDV----YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILK 1114
            |..:..||       :|:||||.|    |.....:|...||||..:.:.| ||:|.|.:|.:|||
  Rat   809 DPAIFEERHLKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGP-EQQRDFQREIQILK 872

  Fly  1115 QYDHPNIVKLIGICV--QKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLE 1177
            ......|||..|:..  .:|.:.:|||.:..|.|..:|:::...|...:.:........||.||.
  Rat   873 ALHCDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLHNDRLLLFAWQICKGMEYLG 937

  Fly  1178 SKNCIHRDLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNFGKYT 1238
            ::.|:||||||||.||:.|..|||:|||:::    .::.|:|.: ..|.|:.|.|||:|:...::
  Rat   938 ARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVRE-PGQSPIFWYAPESLSDNIFS 1001

  Fly  1239 SLCDVWSYGILMWEIFSKGDTPYSGMTN--------------SRARERIDTGYRMPTPKSTPEEM 1289
            ...||||:|::::|:|:..|...|..|.              ....|.:..|.|:|.|.:.|.|:
  Rat  1002 RQSDVWSFGVVLYELFTYSDKSCSPSTEFLRMMGPEREGSPLCHLLELLAEGRRLPPPSTCPTEV 1066

  Fly  1290 YRLMLQCWAADAESRPHFDEIYNVVDAL 1317
            ..||..||:.:.:.||.||.:...:|||
  Rat  1067 QELMQLCWSPNPQDRPAFDTLSPQLDAL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	91/278 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/278 (33%)
Jak3	NP_036987.2	cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..223
		FERM_F1	41..114	CDD:408179
		FERM_F2	126..245	CDD:408177
		FERM_C_JAK3	250..359	CDD:275413
		SH2	359..455	CDD:417686
		PKc_like	517..774	CDD:419665
		PKc_like	813..1095	CDD:419665	94/284 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810