Protein Alignment FER and Fgfr2

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_036844.1
• Gene: Fgfr2 / 25022
• RGDID: 2611
• Length: 841
• Species: Rattus norvegicus
• Alignment Length: 437
• Identity: 125/437 - (28%)
• Similarity: 191/437 - (43%)
• Gaps: 70/437 - (16%)

  Fly   921 EEEDSASDDVLSMKDHCYCVPSLAASI--------SLSTNRPLYEEE-WFHGVLPREEVVRLLNN 976
            |:|.:||.|.|.:..:|..|..:|..:        ..:|.:|.:..: ..|.:..|..:.|
  Rat   386 EKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRR---- 446

  Fly   977 DGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTV 1041
                  :.|:..|.|..:.|      ...:|:.|...:...:.|..|.:.|.       |||...
  Rat   447 ------QVTVSAESSSSMNS------NTPLVRITTRLSSTADTPMLAGVSEY-------ELPEDP 492

  Fly  1042 KSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKTCRMTLP 1099
            |             ||...|.:.|.:.:|.|.||.|..|:......|       ||||..:....
  Rat   493 K-------------WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDAT 544

  Fly  1100 DEQKRKFLQEGRILKQY-DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN---------- 1153
            ::.....:.|..::|.. .|.||:.|:|.|.|..|:.:::|....|:|..|||..
  Rat   545 EKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYD 609

  Fly  1154 -----SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EE 1211
                 ...:|.:..:......|.||.||.|:.||||||||||.||...:.:||:|||::|:  ..
  Rat   610 INRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 674

  Fly  1212 EYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTG 1276
            :|.......::||||.|||||....||...||||:|:||||||:.|.:||.|:......:.:..|
  Rat   675 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 739

  Fly  1277 YRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            :||..|.:...|:|.:|..||.|....||.|.::...:|.::....|
  Rat   740 HRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/86 (17%)
		TyrKc	1063..1311	CDD:197581	93/272 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	92/272 (34%)
Fgfr2	NP_036844.1	Ig	50..143	CDD:416386
		Ig strand A	50..53	CDD:409353
		Ig strand A'	66..72	CDD:409353
		Ig strand B	75..85	CDD:409353
		Ig strand C	88..93	CDD:409353
		Ig strand C'	96..98	CDD:409353
		Ig strand D	103..107	CDD:409353
		Ig strand E	110..115	CDD:409353
		Ig strand F	121..130	CDD:409353
		Ig strand G	133..143	CDD:409353
		IgI_2_FGFR	173..267	CDD:409443
		Ig strand B	194..198	CDD:409443
		Ig strand C	207..211	CDD:409443
		Ig strand E	233..237	CDD:409443
		Ig strand F	247..252	CDD:409443
		Ig strand G	260..263	CDD:409443
		Ig	275..377	CDD:416386
		Ig strand A	275..278	CDD:409353
		Ig strand A'	282..286	CDD:409353
		Ig strand B	294..301	CDD:409353
		Ig strand C	305..312	CDD:409353
		Ig strand D	327..332	CDD:409353
		Ig strand E	342..347	CDD:409353
		Ig strand F	355..363	CDD:409353
		Ig strand G	366..374	CDD:409353
		FGFR3_TM	391..421	CDD:407957	7/29 (24%)
		PTKc_FGFR2	476..788	CDD:270679	105/331 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810