DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and ABL1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_009297.2	Gene:	ABL1 / 25	HGNCID:	76	Length:	1149	Species:	Homo sapiens

Alignment Length:	391	Identity:	139/391 - (35%)
Similarity:	214/391 - (54%)	Gaps:	44/391 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 LYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFR 1016
            |.:..|:||.:.|.....||::  :|.|||||: .:...|..:|:.:.|. .|:.:.|..:|...
Human   141 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRES-ESSPGQRSISLRYEGRVYHYRINTASDGKLY 204

  Fly  1017 FEGPP-FASIQELIMHQYHSELPVTVKSGAI--LRRPVCR-------------ERWELSNDDVVL 1065
            ..... |.::.||:.|  ||    ||..|.|  |..|..:             ::||:...|:.:
Human   205 VSSESRFNTLAELVHH--HS----TVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITM 263

  Fly  1066 LERIGRGNFGDVYKAKLKSTKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICV 1129
            ..::|.|.:|:||:...|...|.|||||.:. |:..|:   ||:|..::|:..|||:|:|:|:|.
Human   264 KHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE---FLKEAAVMKEIKHPNLVQLLGVCT 325

  Fly  1130 QKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMG------MCRDAAAGMRYLESKNCIHRDLAA 1188
            ::.|..|:.|.:..|:||.|||:     ..||::.      |....::.|.|||.||.|||||||
Human   326 REPPFYIITEFMTYGNLLDYLRE-----CNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAA 385

  Fly  1189 RNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMW 1251
            |||||...|.||::|||:||  ..:.|....|.| .|:||||||:|.:.|::...|||::|:|:|
Human   386 RNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKFSIKSDVWAFGVLLW 449

  Fly  1252 EIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDA 1316
            ||.:.|.:||.|:..|:..|.::..|||..|:..||::|.||..||..:...||.|.||:...:.
Human   450 EIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFET 514

  Fly  1317 L 1317
            :
Human   515 M 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/87 (29%)
		TyrKc	1063..1311	CDD:197581	104/256 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/256 (41%)
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784
		SH2_ABL	142..235	CDD:198189	29/99 (29%)
		PTKc_Abl	254..516	CDD:270645	108/271 (40%)
		Pkinase_Tyr	261..512	CDD:285015	105/259 (41%)
		FABD	1025..1149	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810