DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Insr

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_058767.2	Gene:	Insr / 24954	RGDID:	2917	Length:	1384	Species:	Rattus norvegicus

Alignment Length:	1126	Identity:	267/1126 - (23%)
Similarity:	444/1126 - (39%)	Gaps:	300/1126 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 QELEG-----AVRDCQEKQMKMIEHVNGGSPVANGSIISN---GSNTSNGIQSNKDSL------- 365
            |.|||     :|...||.:         |..|.|||:|.|   |:|.:..:::|...:
  Rat   340 QILEGEKTIDSVTSAQELR---------GCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFL 395

  Fly   366 -CRQSKDLNALRCQEKQKQKLVDMIKCALNEVG-----------CEELPSGCDDDLTLEQNFIEN 418
             .|:|..|.:|....|     :.:|:....|:|           ..:|......:||:.|..:..
  Rat   396 KIRRSYALVSLSFFRK-----LHLIRGETLEIGNYSFYALDNQNLRQLWDWNKHNLTITQGKLFF 455

  Fly   419 GYN------------------NEQQRSN---STSSPGLGIMNELMRRGGVLT-----LLRGRGRH 457
            .||                  ..|:|::   .|:.......|||::...:.|     |||.
  Rat   456 HYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRW---- 516

  Fly   458 FKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYL 522
                   :|..|..      |..|      ||.:...::      |.|:.:|          .:.
  Rat   517 -------EPYWPPD------FRDL------LGFMLFYKE------APYQNVT----------EFD 546

  Fly   523 GEEIATSST------NPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQ---LTAAVLTNTNNN 578
            |::...|::      :||..:...::|.      ......::....|.||   ....::|.::..
  Rat   547 GQDACGSNSWTVVDIDPPQRSNDPKSQT------PSHPGWLMRGLKPWTQYAIFVKTLVTFSDER 605

  Fly   579 HIY---ADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTA-PQNSIDAHL---DRIDELNRV 636
            ..|   :|:...:...|:||.......:.....||.::....: |..:|..:|   :|..|.:.:
  Rat   606 RTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSEL 670

  Fly   637 --LDDRLK------RTLQP---SDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKD 690
              ||..||      ||..|   |||       .:.|.|:            ....|:|||.|...
  Rat   671 FELDYCLKGLKLPSRTWSPPFESDD-------SQKHNQS------------EYDDSASECCSCPK 716

  Fly   691 TSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTN 755
            |.              |.|   |||..:|...:..::::.|.....::|       |||
  Rat   717 TD--------------SQI---LKELEESSFRKTFEDYLHNVVFVPRKT-------SSG------ 751

  Fly   756 SSSSSSNNNNNNKNTSSNSNHSASQSTI-----ITSTITTTITTTTTTTPSKENSRLKFKVPKIQ 815
            :.:..:..:...::.....|.:|:..|:     |:|||..|         |.|..|...||  :.
  Rat   752 NGAEDTRPSRKRRSLEEVGNVTATTPTLPDFPNISSTIAPT---------SHEEHRPFEKV--VN 805

  Fly   816 KKSKAIRNTFRSKLLNFQLKR--SKPCKQCTKRRRIHPSKSVFDFAK---EFEVEQPAGSAADEQ 875
            |:|..|     |.|.:|...|  .:.|.|.:...|.  |.:.:..|:   |.:.:...|....|.
  Rat   806 KESLVI-----SGLRHFTGYRIELQACNQDSPEERC--SVAAYVSARTMPEAKADDIVGPVTHEI 863

  Fly   876 FCN--CPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHC- 937
            |.|  .....|:|.:|:..|             .|.|.|.|.. .|||.....|....:::..|
  Rat   864 FENNVVHLMWQEPKEPNGLI-------------VLYEVSYRRY-GDEELHLCVSRKHFALERGCR 914

  Fly   938 --------YCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIV 994
                    |.|...|.  ||:.|....|..:|:..              |:|   .:.:..::|:
  Rat   915 LRGLSPGNYSVRVRAT--SLAGNGSWTEPTYFYVT--------------DYL---DVPSNIAKII 960

  Fly   995 L---------SVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRP 1050
            :         ||.......|:.:...:|..   ||.:||...    :|.|...|...|..:
  Rat   961 IGPLIFVFLFSVVIGSIYLFLRKRQPDGPM---GPLYASSNP----EYLSASDVFPSSVYV---- 1014

  Fly  1051 VCRERWELSNDDVVLLERIGRGNFGDVYKAKLK-----STKLDVAVKTCRMTLPDEQKRKFLQEG 1110
              .:.||:..:.:.||..:|:|:||.||:...|     ..:..|||||...:....::.:||.|.
  Rat  1015 --PDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEA 1077

  Fly  1111 RILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR------KNSNGL---TTRQQMGMC 1166
            .::|.:...::|:|:|:..:.||.::||||:..|.|.::||      :|:.|.   |.::.:.|.
  Rat  1078 SVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMT 1142

  Fly  1167 RDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAP 1229
            .:.|.||.||.:|..:|||||||||:|..:.:|||.||||:|:  |.:|....|...:||:|.:|
  Rat  1143 AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSP 1207

  Fly  1230 EALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERI-DTGYRMPTPKSTPEEMYRLM 1293
            |:|..|.:|:..|:||:|:::|||.|..:.||.|::|.:..:.: |.||..| |.:.||.:..||
  Rat  1208 ESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDP-PDNCPERLTDLM 1271

  Fly  1294 LQCWAADAESRPHFDEIYNVV 1314
            ..||..:.:.||.|.||.|::
  Rat  1272 RMCWQFNPKMRPTFLEIVNLL 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/94 (16%)
		TyrKc	1063..1311	CDD:197581	97/264 (37%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/265 (37%)
Insr	NP_058767.2	Recep_L_domain	52..164	CDD:279382
		Furin-like	179..337	CDD:279142
		FU	234..281	CDD:238021
		Recep_L_domain	359..472	CDD:279382	24/117 (21%)
		FN3	624..>667	CDD:238020	8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..710		7/40 (18%)
		Insulin-binding. /evidence=ECO:0000250	735..743		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..784		7/48 (15%)
		FN3	869..946	CDD:238020	21/92 (23%)
		Important for interaction with IRS1, SHC1 and STAT5B	998..1001		0/6 (0%)
		PTKc_InsR	1018..1305	CDD:133192	101/276 (37%)
		Pkinase_Tyr	1025..1292	CDD:285015	99/267 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1362..1384
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910