DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and ros1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_009291185.1	Gene:	ros1 / 245951	ZFINID:	ZDB-GENE-020506-1	Length:	1443	Species:	Danio rerio

Alignment Length:	1377	Identity:	284/1377 - (20%)
Similarity:	467/1377 - (33%)	Gaps:	462/1377 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 LHLTHNEYVLSITEAIEVEKDFRNVLLPGL-------------LEHQQSVQESFILLWRNILQE- 233
            |:||.|::.:|......|   |.|...|..             .|.|.||.|:.|.....:.|:
Zfish   191 LNLTSNKHKISAATGGNV---FSNTFYPTFHNTTYRISIAAVNEEGQGSVAEASITTPAQVGQDG 252

  Fly   234 -----AAQYGDL-----TADKYKEIQKRIDTVI-GSI-------NPTEEYGEFTEKYKTSPTTPL 280
                 |:::..|     .||.:...|...|:.| |:|       |....|.....:........|
Zfish   253 GRWVFASRWSSLRMREEDADFFTTAQCLSDSRIEGNITGVAVHYNSNHVYFSEGSRIWVKGAGNL 317

  Fly   281 LFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEG------AVRDCQEKQMKMIE-HVNG 338
            ....|..|:...|       |.|..||||||..|:....|      .:.||    :..:: :||.
Zfish   318 TDHSDLKLLHTAP-------LEVTALTVDWLYLRIYYASGGRIHYCGLDDC----LSPVDTNVNL 371

  Fly   339 GSPVANGSIISNGSN------TSNGIQSNKDSLCRQSKDLNALRCQEKQKQKLVDMIKCALNEVG 397
            .|...|  ||::..|      .|.||..            :.|.....|:|::..:||
Zfish   372 SSDAVN--IIADPYNGWLYMLLSTGIYR------------SPLPDVSSQQQEISHIIK------- 415

  Fly   398 CEELPSGCDDDLTLEQNFIEN-------GYNNEQQRSNSTSSPGLGIM----------NELMRRG 445
               :||        ..||:.:       .::...|..|:||..||..:          |.::...
Zfish   416 ---MPS--------VSNFVVSFPNKRIVYHDRSDQTLNATSLDGLFPITLYTNVNFEANSIVYED 469

  Fly   446 GVLTLLRGRGRHFKRKSTPQPATP----------MTRSRQGRFNKLQPRSQSLGSLSVIRDGNGP 500
            ....|..|...:   |...|...|          :..|..|.|:.|...|.|
Zfish   470 NFFMLTNGYAVY---KQVGQSQVPTFFEFAMDCDIIHSENGGFDNLCYFSTS------------- 518

  Fly   501 SPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDE--------EPVV 557
              |:..|:..                     .|.||         .:..|.|:        |.::
Zfish   519 --AQLYPVPR---------------------KPKDL---------QVLFGSDKAYVYWNKPESMM 551

  Fly   558 LASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNS 622
            .|||:.....|.|:....|...:.:..|:.....|.|..:        ..:...:.:...:|..
Zfish   552 GASPSAWQNWTYAINCTMNGLVVMSIREVTSTYATVPDLQ--------SSQHYNVTVRACSPGG- 607

  Fly   623 IDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRS 687
                      .:|.|... ..||.|:|:...|.:|.:..|    |.:|.|
Zfish   608 ----------CSRSLSYE-GTTLHPADEPPYIAAASDGDI----LKQDLD--------------- 642

  Fly   688 SKDTSHSKKRSLSFSQKSISNIFSNLKE---FSKSPLVRMGKNHI----LNEEQDAKRTQPSQHH 745
                      ::.|.::.:| :..::|:   ::.:........||    ||....:..|.||...
Zfish   643 ----------NIEFMEQIVS-LIGDVKDMDWYNSTIYWTNSSGHINWFDLNNRSLSVMTMPSTPV 696

  Fly   746 HSSGS-----------DCPTNSSSSSSNNNNNNKNTSSNSNHSASQS-----TIITSTITTTITT 794
            |:...           .|.||.....|        ||..:.....|:     :::..::...|..
Zfish   697 HAEALAFDWLGQYLYWSCNTNQICRGS--------TSGQAVEIFLQADQKILSLVIDSLNAAIYW 753

  Fly   795 TTTTTPSK-----ENSRLKFKVPKIQKKSKA-------------------IRNTFRSKLLNFQLK 835
            ||.|:...     |..:|..|:.....|..|                   :.|.:|..:...:::
Zfish   754 TTETSVEACRLDGEGFQLLDKLSVFSGKEVAGVTLNMIEGNLYWLVQDGSLLNLYRVNISGDRMQ 818

  Fly   836 RSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHP 900
            :||                ..:|||                           ..:.||..|:...
Zfish   819 KSK----------------AVEFAK---------------------------WTTSQIFDHQVSY 840

  Fly   901 FESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHC----------------------YCVPSL 943
            :......||||....|     :|.:.::.||...::.                      ..:|..
Zfish   841 YSERLVWLDENKQLRI-----QELNQNNSVLMSSNNTLTAFSVVQKMLKPLPDGFVSPPVVIPPA 900

  Fly   944 AASISLSTNRPLYEEEW----------FHGVLPREEVVRLLNNDGDFLVR---------ETIRN- 988
            .:.|.|..|...::..|          |:.|:.:|....|......|..|         ||:.|
Zfish   901 VSKIVLVGNASFFQIHWEPSSVDYGTVFYCVVSKEVWKNLDPLPNMFPTRYCHPVNTFTETVINV 965

  Fly   989 ------EESQIVLS------------------------------------------------VCW 999
                  .|..|.::                                                |.|
Zfish   966 TRFKPGAELNITITPFSYWGKGKSTETILITPAGTSDTDKTLIIAIVSVAVGVTLIILILAVVIW 1030

  Fly  1000 NGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSG--AILRRPVCRERWELSN-- 1060
            ..|.      ..:.:.:.:.|....|...:..:|...| |.:::|  ||...|   .|.|:.:
Zfish  1031 QRHH------KKKDHGKAKQPSSVQIHPDVELEYVRGL-VGLENGCFAISNTP---SRAEIESLP 1085

  Fly  1061 ---DDVVLLER-IGRGNFGDVYKAKLKSTKLD-------VAVKTCRMTLPDEQKRKFLQEGRILK 1114
               .|.:.|:| :|.|.||:||:.....::::       ||:||.:....|.:|.:||:|..::.
Zfish  1086 VFPRDCLKLQRLLGSGAFGEVYEGVTVGSQINGVEPERKVAIKTLQKDASDYEKTEFLKEAHLMS 1150

  Fly  1115 QYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR--KNSNG----LTTRQQMGMCRDAAAGM 1173
            |::||||::|:|:|:..:|..:::||:.||.|.:|||  :.:|.    |:....:.:..|||.|.
Zfish  1151 QFNHPNILRLLGVCLLNEPHYLILELMEGGDLRSYLRGARPTNNHKELLSLSSLLDISLDAATGC 1215

  Fly  1174 RYLESKNCIHRDLAARNCLV------DLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPE 1230
            .|||..:.:|||:|||||||      |.|..|||.|||::|:  :.:|....|...:||:|.:||
Zfish  1216 AYLERMHFVHRDIAARNCLVSVRTYTDPERVVKIGDFGLARDVYKNDYYRKKGEGLLPVRWMSPE 1280

  Fly  1231 ALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQ 1295
            :|..|.:....|||::|:|:|||.:.|..||...||......|.||.|:.:|...|:.:|.||:.
Zfish  1281 SLTDGIFNKYSDVWAFGVLLWEILTLGKLPYPTYTNHEVLSYISTGGRLSSPAGCPQRLYNLMMS 1345

  Fly  1296 CWAADAESRPHF 1307
            ||:.....||:|
Zfish  1346 CWSKQPADRPNF 1357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	18/83 (22%)
		SH2_Fps_family	953..1039	CDD:198224	19/159 (12%)
		TyrKc	1063..1311	CDD:197581	98/267 (37%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/263 (37%)
ros1	XP_009291185.1	FN3	70..151	CDD:238020
		FN3	156..244	CDD:238020	15/55 (27%)
		FN3	525..618	CDD:238020	18/142 (13%)
		Pkinase_Tyr	1092..1362	CDD:285015	98/266 (37%)
		PKc_like	1096..1364	CDD:304357	97/262 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910