DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and igf1ra

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_694500.1	Gene:	igf1ra / 245701	ZFINID:	ZDB-GENE-020503-1	Length:	1405	Species:	Danio rerio

Alignment Length:	1158	Identity:	240/1158 - (20%)
Similarity:	412/1158 - (35%)	Gaps:	351/1158 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 MKMIEHVNGGSPVANGSIISNGS---NTSNGIQSNK--DSLCRQSKDLNALRCQEKQKQKLVDMI 389
            |:|...|:..|.|  ..:|.||.   :...|...|:  ...|.....|    |.:..:.|.:|.:
Zfish   285 MEMCARVHLPSEV--DFVIHNGECMPDCPPGFTRNETLSMFCSACDGL----CDKVCESKTIDSV 343

  Fly   390 KCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRG- 453
            ..|.:..||..:..      .|:.| |..|.|               |.:||....|::..:.|
Zfish   344 DAAQSLQGCTVIKG------NLQIN-IRRGNN---------------IASELESFMGLIQTVTGY 386

  Fly   454 -RGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARY------------ 505
             |.:|                           :.:|||||.::.      .||
Zfish   387 VRIKH---------------------------THTLGSLSFLKS------LRYIVGEELVDNTYA 418

  Fly   506 -EPITNHRLRQAASVHYLGEEIATSST----------NPP----------DLTRLRRTQCSMLCL 549
             ..:.||.|:      ||.:....:.|          ||.          :.|.:|..      :
Zfish   419 FHAVDNHNLQ------YLWDWTQHNLTIRTGKLYFRFNPKLCMSEIRKMWEKTSVREK------M 471

  Fly   550 GEDE----------EPVVLASPAPLTQLTAAVLT-------------------------NT---- 575
            .||:          |..:|...:..||.|...||                         |.
Zfish   472 AEDDVRSNGERASCESYILKFRSNHTQSTRIKLTWERYRPPDYRDLISFIVYYKEAPFQNITEFD 536

  Fly   576 ------NNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELN 634
                  :|:....|::|.::|...|     |..:.|.|...:..|              .:..:.
Zfish   537 GQDGCGSNSWNMVDVDLPQEKSIDP-----GVLLSPLKPWTQYAI--------------FVKAVT 582

  Fly   635 RVLDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDP----DSQTKRSSSSSSECRSSKDTSHSK 695
            .|::|:            .:..|:...:..|..|..|    |::...:||||...:.|...:.:.
Zfish   583 LVVEDK------------HVGGAKSEVVYIRTNASAPSMPLDARAYANSSSSLMVKWSPPIAPNG 635

  Fly   696 KRS---LSFSQKSIS------NIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSG-S 750
            .::   |.:.|::..      |..|  ||. |.| :|:....:.:.|.:.|.|:........| .
Zfish   636 NKTFYVLRWQQQAEDGELYQHNYCS--KEL-KIP-IRISATSLSDMEGETKPTKSDVAGGEKGCC 696

  Fly   751 DCP-TNSSSSSSNNNNNNKNTSSNSNHSA-----------------SQSTIITS-TITTTITTTT 796
            .|| |.....:...:.:.:....|..|::                 :.||:::. :...::..:.
Zfish   697 PCPKTKEDLKAEAEDRSYRKVFENFLHNSIFTPRPPDRKRRDLMGVANSTLVSGVSRNISVLESN 761

  Fly   797 TTTPSKENSRLKFKVPKIQKKSKAIRN-----------------TFRSKLLNFQLKRSKPCKQC- 843
            .|.|........|...|:..:...|.|                 ..|.....|...|:||..:.
Zfish   762 ITQPELPEKEYPFSEGKVHTEFMEIHNLRPFTVYRIDIHACNYEVHRCSAAAFVFSRTKPADKAD 826

  Fly   844 ------TKRR--------------RIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVK 888
                  |:.|              .:||:..:.    .:|::...|:.|::.  .|....|..|.
Zfish   827 DIPGSVTQERDEKGEGIVLLRWPEPLHPNGLIL----MYEIKYRLGTEAEKH--ECVSRQQYKVL 885

  Fly   889 PSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNR 953
            ...|:|       ..:||...                                :...:.||:.|.
Zfish   886 RGAQLS-------NLASGNYS--------------------------------ARVRATSLAGNG 911

  Fly   954 PLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRF- 1017
            ...|...|:...|:.      |.|....|...|    ..|||.:........|:.|....:.|.
Zfish   912 SWTEPVSFYVPPPKR------NYDNALYVAIII----PVIVLLLLLFVIVAVIIVTKKRNSDRIG 966

  Fly  1018 EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL 1082
            .|..:||:..    :|.|...:.|.           :.||::.:.:.:...:|:|:||.||:...
Zfish   967 NGVLYASVNP----EYFSPFEMYVP-----------DEWEVAREKITMCRELGQGSFGMVYEGIA 1016

  Fly  1083 KSTKLD-----VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVL 1142
            |....|     ||:||...:....::.:||.|..::|:::..::|:|:|:..|.||.:::|||:.
Zfish  1017 KGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMT 1081

  Fly  1143 GGSLLTYLR--------KNSNGLTTRQQM-GMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHS 1198
            .|.|.::||        .:|..|...::| .|..:.|.||.||.:...:|||||||||:|..:.:
Zfish  1082 RGDLKSHLRSLRSKEQGSSSQSLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFT 1146

  Fly  1199 VKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPY 1261
            |||.||||:|:  |.:|....|...:||:|.:||:|..|.:|:..||||:|:::|||.:..:.||
Zfish  1147 VKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPY 1211

  Fly  1262 SGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVV 1314
            .||:|.:....:..|..:..|.:.|:.::.||..||..:.:.||.|.||.|.:
Zfish  1212 QGMSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIINSI 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/86 (21%)
		TyrKc	1063..1311	CDD:197581	91/263 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	93/264 (35%)
igf1ra	NP_694500.1	Recep_L_domain	51..167	CDD:279382
		Furin-like	182..333	CDD:279142	13/53 (25%)
		FU	235..275	CDD:214589
		Recep_L_domain	351..465	CDD:279382	29/174 (17%)
		FN3	497..602	CDD:238020	18/135 (13%)
		FN3	607..>651	CDD:238020	9/43 (21%)
		FN3	844..921	CDD:238020	17/121 (14%)
		PTKc_IGF-1R	990..1266	CDD:133193	95/275 (35%)
		Pkinase_Tyr	997..1264	CDD:285015	93/266 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910