DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Met

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_113705.1	Gene:	Met / 24553	RGDID:	3082	Length:	1382	Species:	Rattus norvegicus

Alignment Length:	1398	Identity:	295/1398 - (21%)
Similarity:	467/1398 - (33%)	Gaps:	471/1398 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 VRKKSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQ-KACRKLHLTHNEYVLSITEA 197
            ||:..|.|   :|:|.|.   :::||..       |.:.||.|. |........|..|.|::.:.
  Rat   217 VRRLKETQ---DGFKFLT---DQSYIDV-------LGEFRDSYPIKYIHAFESNHFIYFLTVQKE 268

  Fly   198 IEVEKDFRNVLL------PGLLEHQQSVQESFILLWR----------NILQE------------- 233
            ....:.|...::      .||..:.:...|..:...|          ||||.
  Rat   269 TLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQ 333

  Fly   234 --AAQYGDL---------------------TADKYKEIQKRIDTVIGSIN---------PTEEY- 265
              |:.|.|:                     .|...|.:....:.::...|         |..|:
  Rat   334 IGASPYDDILYGVFAQSKPDSAEPMNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHC 398

  Fly   266 ------------GEFTEKYKTSPTTPL----LF--QFDETLIQDIPGKLQSSTLTVDNLTVDWLR 312
                        ...:::|:|..||.|    ||  :.:..|:..|      ||....:||:
  Rat   399 FNRTLLRNSSGCEVRSDEYRTEFTTALQAVDLFMGRLNHVLLTSI------STFIKGDLTI---- 453

  Fly   313 NRLQELEGA-VRDCQEKQMKMIEHVN---GGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLN 373
            ..|...||. ::....:......|||   ...||:...|:.:.|| .||.     :|....|.:.
  Rat   454 ANLGTSEGRFMQVVLSRTAHFTPHVNFLLDSHPVSPEVIVEHPSN-QNGY-----TLVVTGKKIT 512

  Fly   374 ALRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGY-NNEQQRSNS-------- 429
                            |..||.:||....| |...|:... ||:.|: :|....||.
  Rat   513 ----------------KIPLNGLGCGHFQS-CSQCLSAPY-FIQCGWCHNRCVHSNECPSGTWTQ 559

  Fly   430 ------------TSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQ 482
                        ||:|         ..||.:..:.|....||:.                 ||..
  Rat   560 EICLPAVYKVFPTSAP---------LEGGTMLTICGWDFGFKKN-----------------NKFD 598

  Fly   483 PRSQSLGSLSVIRDGNGPSPARYEPITNHRLR----QAASVHYLGEEIATSSTNPPDLTRLRRTQ 543
            .|.      :.:..||..........|.:.|:    .|.|.|:....|.::|.        ..||
  Rat   599 LRK------TKVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIVSNSR--------ETTQ 649

  Fly   544 CSMLCLGEDEEPVVLA-SP-------APLTQLTAAVLTNTNNNHIYADLELDKKKDTSPS-PECK 599
            .|....   .:||:.: ||       ..|..||...|.:.|:.||....:....|..|.| .||
  Rat   650 YSAFSY---VDPVITSISPRYGPHAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILEC- 710

  Fly   600 GEQIQPKKEQIRIEINQTAPQNSIDAHLD---RIDELNRVLDDRLKRTLQPSDD--VNAIESAEE 659
                             ..|.:::.|...   :||     |.||:..:....:|  |:.|...:.
  Rat   711 -----------------YTPGHTVSAEFPVKLKID-----LADRVTSSFSYGEDPFVSEIHPTKS 753

  Fly   660 ---------------NHIQTRKLAKDPD--------SQTKRSSSSSSECRSSKDTSHSKKRSLSF 701
                           |.:.|.||..:..        :...||||....|    .|...::..|..
  Rat   754 FISGGSTITGIGKNLNSVSTPKLVIEVHDVGVNYTVACQHRSSSEIICC----TTPSLQQLDLQL 814

  Fly   702 SQKS-----ISNIFSN-----------LKEFSKSPLVRMGKNHILNEEQD--------------A 736
            ..|:     :..|.|.           .|.|.|..::.||..:::..:.|              .
  Rat   815 PLKTKAFFLLDGILSKHFDLTYVHDPMFKPFEKPVMISMGNENVVEIKGDDIDPEAVKGEVLKVG 879

  Fly   737 KRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPS 801
            .::..:.|.||....|...|.....|....|....     .|..||::...|         ..|.
  Rat   880 NKSCENLHWHSEALLCTVPSDLLKLNGGELNIEWK-----QAVSSTVLGKVI---------VQPD 930

  Fly   802 KENSRLKFKVPKIQ-------------KKSKAIRNTFRSKLLNFQLKRSKP-CKQCTKRRRIHP- 851
            :..:.|......|.             :|.|  .....|:|:.:..:...| ..:....|.:.|
  Rat   931 QNFAGLIIGAVSISVVVLLVSGLFLWLRKRK--HKDLGSELVRYDARVHTPHLDRLVSARSVSPT 993

  Fly   852 ----SKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENS 912
                |....|:...|         .::||   |.:.|......||      :|....|..| .:.
  Rat   994 TEMVSNESVDYRATF---------PEDQF---PNSSQNGACRQVQ------YPLTDLSPIL-TSG 1039

  Fly   913 DRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNND 977
            |.||          |..:|....|          |.||...|
  Rat  1040 DSDI----------SSPLLQNTVH----------IDLSALNP----------------------- 1061

  Fly   978 GDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVK 1042
                          ::|.:|     :|.::           ||     ..||:|
  Rat  1062 --------------ELVQAV-----QHVVI-----------GP-----SSLIVH----------- 1080

  Fly  1043 SGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKST---KLDVAVKTCRMTLPDEQKR 1104
                                  ..|.||||:||.||...|..:   |:..|||:.......|:..
  Rat  1081 ----------------------FNEVIGRGHFGCVYHGTLLDSDGKKIHCAVKSLNRITDIEEVS 1123

  Fly  1105 KFLQEGRILKQYDHPNIVKLIGICVQKQ--PIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCR 1167
            :||.||.|:|.:.|||::.|:|||::.:  | ::|:..:..|.|..::|..::..|.:..:|...
  Rat  1124 QFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL 1187

  Fly  1168 DAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR---EEEEYIVSD--GMKQIPVKWT 1227
            ..|.||:||.||..:|||||||||::|.:.:||::|||::|   ::|.|.|.:  |.| :||||.
  Rat  1188 QVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAK-LPVKWM 1251

  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292
            |.|:|...|:|:..||||:|:|:||:.::|..||..:........:..|.|:..|:..|:.:|.:
  Rat  1252 ALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEV 1316

  Fly  1293 MLQCWAADAESRPHFDEIYNVVDALILRLDNSH 1325
            ||:||...||.||.|.|:.:.:.::.......|
  Rat  1317 MLKCWHPKAEMRPSFSELVSRISSIFSTFIGEH 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	29/161 (18%)
		SH2_Fps_family	953..1039	CDD:198224	9/85 (11%)
		TyrKc	1063..1311	CDD:197581	98/257 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	98/257 (38%)
Met	NP_113705.1	Sema	25..517	CDD:301699	63/344 (18%)
		PSI	520..562	CDD:214655	11/43 (26%)
		IPT_plexin_repeat1	564..657	CDD:238585	23/135 (17%)
		IPT_plexin_repeat2	658..739	CDD:238584	23/103 (22%)
		IPT	743..838	CDD:301692	16/98 (16%)
		IPT	839..>903	CDD:214657	11/63 (17%)
		Pkinase_Tyr	1079..1338	CDD:285015	99/293 (34%)
		PTKc_Met_Ron	1083..1344	CDD:270649	98/262 (37%)
		Interaction with RANBP9. /evidence=ECO:0000250	1213..1382		48/138 (35%)
		Interaction with MUC20. /evidence=ECO:0000250	1321..1360		8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900