DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Jak2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_113702.1	Gene:	Jak2 / 24514	RGDID:	2939	Length:	1132	Species:	Rattus norvegicus

Alignment Length:	294	Identity:	94/294 - (31%)
Similarity:	154/294 - (52%)	Gaps:	32/294 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1053 RERWELSNDDVVLLERIGRGNFGDV----YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRIL 1113
            |:..:.....:..|:::|:||||.|    |.....:|...||||..:.: .:|..|.|.:|..||
  Rat   839 RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS-TEEHLRDFEREIEIL 902

  Fly  1114 KQYDHPNIVKLIGICVQ--KQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYL 1176
            |...|.||||..|:|..  ::.:.::||.:..|||..||:|:...:..::.:........||.||
  Rat   903 KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYL 967

  Fly  1177 ESKNCIHRDLAARNCLVDLEHSVKISDFGMSR---EEEEYIVSDGMKQIPVKWTAPEALNFGKYT 1238
            .:|..||||||.||.||:.|:.|||.|||:::   :::||.......:.|:.|.|||:|...|::
  Rat   968 GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFS 1032

  Fly  1239 SLCDVWSYGILMWEIFS---KGDTP---YSGMTNSRAR---------ERIDTGYRMPTPKSTPEE 1288
            ...||||:|::::|:|:   |..:|   :..|..:..:         |.:....|:|.|:..|:|
  Rat  1033 VASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPEGCPDE 1097

  Fly  1289 MYRLMLQCWAADAESRPHFDEIYNVVDALILRLD 1322
            :|.:|.:||..:...||.|.:       |.||:|
  Rat  1098 IYVIMTECWNNNVNQRPSFRD-------LSLRVD 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	89/271 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	88/271 (32%)
Jak2	NP_113702.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239
		FERM_F1	39..134	CDD:408179
		FERM_F2	143..261	CDD:408177
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663
		PTKc_Jak2_rpt2	844..1127	CDD:271107	93/289 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810