Protein Alignment FER and FRK

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_002022.1
• Gene: FRK / 2444
• HGNCID: 3955
• Length: 505
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 138/393 - (35%)
• Similarity: 222/393 - (56%)
• Gaps: 45/393 - (11%)

  Fly   949 LSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSVCWNGH--KHFIV 1007
            ::.:|.|..|.||.|.:.|.:..:.|    |..|.||:||: .:::.:..|||. :|.  ||:.:
Human   105 VAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRES-ESQKGEFSLSVL-DGAVVKHYRI 167

  Fly  1008 QTTGEGNF-----RFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCR-------------- 1053
            :...||.|     |.    |:::.|.:.|...:...:.||.|    :|..:
Human   168 KRLDEGGFFLTRRRI----FSTLNEFVSHYTKTSDGLCVKLG----KPCLKIQVPAPFDLSYKTV 224

  Fly  1054 ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDH 1118
            ::||:..:.:.||:|:|.|.||:|::....:| ..|||||.:....|  ...||:|.:|:|...|
Human   225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNT-TPVAVKTLKPGSMD--PNDFLREAQIMKNLRH 286

  Fly  1119 PNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG-LTTRQQMGMCRDAAAGMRYLESKNCI 1182
            |.:::|..:|..:.||.|:.||:..|||..||:.::.. :...||:.|....|:||.||||:|.|
Human   287 PKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYI 351

  Fly  1183 HRDLAARNCLVDLEHSV-KISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCD 1242
            ||||||||.||. ||:: |::|||::|    :.|:...|....::|||||||||:...|::...|
Human   352 HRDLAARNVLVG-EHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSD 415

  Fly  1243 VWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            |||:|||::||.:.|..||||||.::..:.:...||:|.|.:.|::.|.:||:||.|:.:.||.|
Human   416 VWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 480

  Fly  1308 DEI 1310
            :.:
Human   481 ETL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/96 (28%)
		TyrKc	1063..1311	CDD:197581	105/254 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/250 (41%)
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779
		SH2_Src_Frk	112..207	CDD:199831	28/104 (27%)
		PTKc_Frk_like	225..494	CDD:270653	107/263 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910