Protein Alignment FER and Egfr

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_113695.2
• Gene: Egfr / 24329
• RGDID: 2543
• Length: 1209
• Species: Rattus norvegicus
• Alignment Length: 1209
• Identity: 255/1209 - (21%)
• Similarity: 426/1209 - (35%)
• Gaps: 370/1209 - (30%)

  Fly   186 THNEYVLSITEAIEVEKDFRN--VLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEI 248
            |..::.||:      ::.|.|  |:| |.||... ||.::.|.:...:||.|.|..:..:..:.|
  Rat    43 TFEDHFLSL------QRMFNNCEVVL-GNLEITY-VQRNYDLSFLKTIQEVAGYVLIALNTVERI 99

  Fly   249 Q-KRIDTVIGSINPTEEYG-EFTEKYKTSPT----TPLLFQFDETLIQDIPGKLQSSTLTVDNLT 307
            . :.:..:.|:......|. .....|.|:.|    .|:. ...|.||..:  :..::.:..:..|
  Rat   100 PLENLQIIRGNALYENTYALAVLSNYGTNKTGLRELPMR-NLQEILIGAV--RFSNNPILCNMET 161

  Fly   308 VDWLRNRLQE--LEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQ-S 369
            :.| |:.:|:  |.....|.|       .|:. |.|..:.| ..|||....|.::     |:: :
  Rat   162 IQW-RDIVQDVFLSNMSMDVQ-------RHLT-GCPKCDPS-CPNGSCWGRGEEN-----CQKLT 211

  Fly   370 KDLNALRCQEKQKQKLVDMIKCALNEVGCEELPSGC----DDDLTLEQNFIENGYNNEQQRSNST 430
            |.:.|.:|..:.:.:  ....|..|:..     :||    :.|..:...|          |..:|
  Rat   212 KIICAQQCSRRCRGR--SPSDCCHNQCA-----AGCTGPRESDCLVCHRF----------RDEAT 259

  Fly   431 ---SSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPAT-PMTRSRQGRFNKLQPRSQSLGSL 491
               :.|.|.:.|                          |.| .|..:.:|::        |.|:.
  Rat   260 CKDTCPPLMLYN--------------------------PTTYQMDVNPEGKY--------SFGAT 290

  Fly   492 SVIRDGNGPSPARYEPITNHR--LRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLC----LG 550
            .|.:     .|..| .:|:|.  :|.....:|..||...|.....|      ..|..:|    :|
  Rat   291 CVKK-----CPRNY-VVTDHGSCVRACGPDYYEVEEDGVSKCKKCD------GPCRKVCNGIGIG 343

  Fly   551 EDEEPVVLASPAPLTQLTAAVLTNTNNNH------IYADLEL-------DKKKDTSPSPECKGEQ 602
            |.::.:.:.:              ||..|      |..||.:       |....|.|....:.|.
  Rat   344 EFKDTLSINA--------------TNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEI 394

  Fly   603 IQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHIQTRKL 667
            ::..||.....:.|..|:|..|.|.....|:.|      .||.|......|:.......:..|.|
  Rat   395 LKTVKEITGFLLIQAWPENWTDLHAFENLEIIR------GRTKQHGQFSLAVVGLNITSLGLRSL 453

  Fly   668 AKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNE 732
            .:..|.                |...|..|:|.::..      .|.|:...:|   ..|..|:|.
  Rat   454 KEISDG----------------DVIISGNRNLCYANT------INWKKLFGTP---NQKTKIMNN 493

  Fly   733 --EQDAKRTQPSQHHHSSGSDC--PTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTIT 793
              |:|.|.|....:...|...|  |..:...|..|.:..:......|....:
  Rat   494 RAEKDCKATNHVCNPLCSSEGCWGPEPTDCVSCQNVSRGRECVDKCNILEGE------------- 545

  Fly   794 TTTTTTPSK--ENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVF 856
                  |.:  |||.                                 |.||      ||.
  Rat   546 ------PREFVENSE---------------------------------CIQC------HPE---- 561

  Fly   857 DFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPF---ESSSGELDENSD----- 913
                           ...|..|....|:.| ...::.:.:.|.|.   ...||.:.||:.
  Rat   562 ---------------CLPQTMNITCTGRGP-DNCIKCAHYVDGPHCVKTCPSGIMGENNTLVWKF 610

  Fly   914 RDIDNDEEEEDSASDDVLSMKDHCYC-------------------VPSLAASISLSTNRPLYEEE 959
            .|.:|            :....|..|                   :||:|..|   ....|:...
  Rat   611 ADANN------------VCHLCHANCTYGCAGPGLKGCQQPEGPKIPSIATGI---VGGLLFIVV 660

  Fly   960 WFHGV---LPREEVVRLLNNDGDFLVRETIRN--EESQIVLSVCWNGHKHFIVQTTGEGNFRFEG 1019
            ...|:   :.|..:||          :.|:|.  :|.::|..:..:|                |.
  Rat   661 VALGIGLFMRRRHIVR----------KRTLRRLLQERELVEPLTPSG----------------EA 699

  Fly  1020 PPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKA---- 1080
            |          :|.|..:                    |...:...::.:|.|.||.|||.
  Rat   700 P----------NQAHLRI--------------------LKETEFKKIKVLGSGAFGTVYKGLWIP 734

  Fly  1081 KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGS 1145
            :.:..|:.||:|..|.....:..::.|.|..::...|:|::.:|:|||: ...:.::.:|:..|.
  Rat   735 EGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICL-TSTVQLITQLMPYGC 798

  Fly  1146 LLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-- 1208
            ||.|:|::.:.:.::..:..|...|.||.|||.:..:||||||||.||.....|||:|||:::
  Rat   799 LLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL 863

  Fly  1209 --EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARE 1271
              ||:||....|  ::|:||.|.|::....||...||||||:.:||:.:.|..||.|:..|....
  Rat   864 GAEEKEYHAEGG--KVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISS 926

  Fly  1272 RIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            .::.|.|:|.|.....::|.:|::||..||:|||.|.|:
  Rat   927 ILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFREL 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	17/58 (29%)
		SH2_Fps_family	953..1039	CDD:198224	14/90 (16%)
		TyrKc	1063..1311	CDD:197581	89/256 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	89/252 (35%)
Egfr	NP_113695.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910