Protein Alignment FER and ALK

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_004295.2
• Gene: ALK / 238
• HGNCID: 427
• Length: 1620
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 136/470 - (28%)
• Similarity: 209/470 - (44%)
• Gaps: 96/470 - (20%)

  Fly   889 PSVQI-SGHKD----HPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDH--------CYCV 940
            |:::: .||.:    |....|..|:||.          ..|..|..|:...||        ..|:
Human   968 PALKVMEGHGEVNIKHYLNCSHCEVDEC----------HMDPESHKVICFCDHGTVLAEDGVSCI 1022

  Fly   941 ------PSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCW 999
                  |.|..|:.||             |:....|..|:......::....:::|.|.:
Human  1023 VSPTPEPHLPLSLILS-------------VVTSALVAALVLAFSGIMIVYRRKHQELQAM----- 1069

  Fly  1000 NGHKHFIVQTTGEGNFRFEGPPFASIQEL----IMHQYHSELPVTVKSGAILRRPVCRERWELSN 1060
                          ....:.|.: .:.:|    ||..|:.......|:.:|      .:..|:..
Human  1070 --------------QMELQSPEY-KLSKLRTSTIMTDYNPNYCFAGKTSSI------SDLKEVPR 1113

  Fly  1061 DDVVLLERIGRGNFGDVYKAKLKS-----TKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPN 1120
            .::.|:..:|.|.||:||:.::..     :.|.|||||......::.:..||.|..|:.:::|.|
Human  1114 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQN 1178

  Fly  1121 IVKLIGICVQKQPIMIVMELVLGGSLLTYLRK------NSNGLTTRQQMGMCRDAAAGMRYLESK 1179
            ||:.||:.:|..|..|::||:.||.|.::||:      ..:.|.....:.:.||.|.|.:|||..
Human  1179 IVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEEN 1243

  Fly  1180 NCIHRDLAARNCLVDLE---HSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTS 1239
            :.||||:||||||:...   ...||.||||:|:  ...|....|...:||||..|||...|.:||
Human  1244 HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 1308

  Fly  1240 LCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESR 1304
            ..|.||:|:|:|||||.|..||...:|....|.:.:|.||..||:.|..:||:|.|||....|.|
Human  1309 KTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR 1373

  Fly  1305 PHFDEIYNVVDALIL 1319
            |:|        |:||
Human  1374 PNF--------AIIL 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	10/89 (11%)
		TyrKc	1063..1311	CDD:197581	101/263 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	100/263 (38%)
ALK	NP_004295.2	MAM	266..427	CDD:279023
		MAM	266..424	CDD:99706
		LDLa	441..467	CDD:197566
		MAM	480..636	CDD:279023
		MAM	480..631	CDD:99706
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..674
		FXa_inhibition	987..1021	CDD:291342	9/43 (21%)
		PTKc_ALK_LTK	1109..1385	CDD:270632	105/280 (38%)
		Pkinase_Tyr	1116..1383	CDD:285015	104/273 (38%)
		Inhibitor binding	1197..1199		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1408..1463
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1540

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910