DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and FLT3

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_004110.2	Gene:	FLT3 / 2322	HGNCID:	3765	Length:	993	Species:	Homo sapiens

Alignment Length:	703	Identity:	172/703 - (24%)
Similarity:	249/703 - (35%)	Gaps:	232/703 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   759 SSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRN 823
            ||...|:....|.|:|.| .|||.::|......|..|        ||...:::.:.::...::|
Human   318 SSVARNDTGYYTCSSSKH-PSQSALVTIVEKGFINAT--------NSSEDYEIDQYEEFCFSVR- 372

  Fly   824 TFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFA-KEFEVEQPA--GSAADEQFCNCPPAGQK 885
                       .::.|..:||           :.|: |.|..||..  ...:..:|||
Human   373 -----------FKAYPQIRCT-----------WTFSRKSFPCEQKGLDNGYSISKFCN------- 408

  Fly   886 PVKPSVQISGHKDHPFESSSGEL---DENSDR--------DIDNDEEEEDSASDDVLSMKDHCYC 939
                      ||..|     ||.   .||.|.        :|....:....||....|.....|.
Human   409 ----------HKHQP-----GEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYP 458

  Fly   940 VPSLAASISLSTNRPLYEEEWFHGVLPRE------------------EVVR-------------- 972
            :||.... ..|...|...||...||..|:                  |.::
Human   459 LPSWTWK-KCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGT 522

  Fly   973 -----LLNNDGDF-LVRETIRNEES---------QIVLSVCWNGHKHF-------IVQTTGEGNF 1015
                 |||:.|.| .:::.|....:         .:.|.:|....|.|       :||.||..:.
Human   523 SCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDN 587

  Fly  1016 RFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDV--- 1077
            .:....|        .:|..:|                 :||...:::...:.:|.|.||.|
Human   588 EYFYVDF--------REYEYDL-----------------KWEFPRENLEFGKVLGSGAFGKVMNA 627

  Fly  1078 --YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQY-DHPNIVKLIGICVQKQPIMIVME 1139
              |........:.||||..:......::...:.|.:::.|. .|.|||.|:|.|....||.::.|
Human   628 TAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFE 692

  Fly  1140 LVLGGSLLTYLRK---------------------------------------------------- 1152
            ....|.||.|||.
Human   693 YCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHG 757

  Fly  1153 NS---------------------NGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLE 1196
            ||                     |.||....:......|.||.:||.|:|:||||||||.||...
Human   758 NSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHG 822

  Fly  1197 HSVKISDFGMSRE---EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGD 1258
            ..|||.|||::|:   :..|:|. |..::||||.|||:|..|.||...||||||||:|||||.|.
Human   823 KVVKICDFGLARDIMSDSNYVVR-GNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGV 886

  Fly  1259 TPYSGM-TNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            .||.|: .::...:.|..|::|..|....||:|.:|..|||.|:..||.|..:
Human   887 NPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	24/139 (17%)
		TyrKc	1063..1311	CDD:197581	103/331 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/327 (31%)
FLT3	NP_004110.2	ig	256..345	CDD:278476	11/27 (41%)
		PKc_like	572..947	CDD:304357	112/394 (28%)
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand	591..597		1/13 (8%)
		Pkinase_Tyr	610..943	CDD:285015	103/331 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910