DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and FLT1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_002010.2	Gene:	FLT1 / 2321	HGNCID:	3763	Length:	1338	Species:	Homo sapiens

Alignment Length:	974	Identity:	213/974 - (21%)
Similarity:	341/974 - (35%)	Gaps:	328/974 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   573 TNTNNNHIYADLELDK--KKD-------TSPSPECKGEQ------------IQPKKEQIRIEINQ 616
            :|::.|..|:.|.:||  .||       ....|..|...            ::.:|:|:
Human   285 SNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQV------ 343

  Fly   617 TAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSS 681
                            |..|..   ||:.:.|..|.|..|.|...:      ||....|::|:..
Human   344 ----------------LETVAG---KRSYRLSMKVKAFPSPEVVWL------KDGLPATEKSARY 383

  Fly   682 SSECRS--SKDTSHSKKRS----LSFSQKSISNIFSNL--------------KEFSKSP---LVR 723
            .:...|  .||.:.....:    ||..|   ||:|.||              |..|..|   |..
Human   384 LTRGYSLIIKDVTEEDAGNYTILLSIKQ---SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYP 445

  Fly   724 MGKNHILN------EEQDAK-RTQPSQHHHSSG--SDCPTNSSS----SSSNNNNNNKNTS---- 771
            :|...||.      .:...| ...|..|:||..  ..|..|..|    :.||..|..::.:
Human   446 LGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMA 510

  Fly   772 --SNSNHSASQSTIITS---------------TITTTITTTTTTTPS------------KENSRL 807
              ...|..||...:..|               |:...|:...|..|:            .|:.:|
Human   511 IIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKL 575

  Fly   808 KFKVPKIQKKSKA--IRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGS 870
            ...|.|...:...  :..|..::.:::.:.:.|  ...||...|..:.::.:.:.     |.:|:
Human   576 SCTVNKFLYRDVTWILLRTVNNRTMHYSISKQK--MAITKEHSITLNLTIMNVSL-----QDSGT 633

  Fly   871 AADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEE----EEDSASDD-- 929
            .|    |..                                  |::...||    :|.:..|.
Human   634 YA----CRA----------------------------------RNVYTGEEILQKKEITIRDQEA 660

  Fly   930 ---VLSMKDHCYCVPSLAASISLSTNRPLYEEEWF---HGVLPREEVVRLLNNDGDFLVRETIRN 988
               :.::.||...:.|.......:...|..:..||   |.:  ::|...:|......|..|.:..
Human   661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKI--QQEPGIILGPGSSTLFIERVTE 723

  Fly   989 EESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQ--------ELI---------------- 1029
            |:..:          :....|..:|:  .|...:.::|        |||
Human   724 EDEGV----------YHCKATNQKGS--VESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLL 776

  Fly  1030 ------MHQYHSELPVTVKSGAIL------------RRPVCRERWELSNDDVVLLERIGRGNFGD 1076
                  |.:..||:.....| .|:            |.|....:||.:.:.:.|.:.:|||.||.
Human   777 TLFIRKMKRSSSEIKTDYLS-IIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGK 840

  Fly  1077 VYKA-----KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHP-NIVKLIGICV-QKQPI 1134
            |.:|     |...|...||||..:......:.:..:.|.:||....|. |:|.|:|.|. |..|:
Human   841 VVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPL 905

  Fly  1135 MIVMELVLGGSLLTYLR------------------------------------------------ 1151
            |:::|....|:|..||:
Human   906 MVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSG 970

  Fly  1152 -------------KNSNG-----LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHS 1198
                         ::|:|     :|....:......|.||.:|.|:.||||||||||.|:...:.
Human   971 FQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035

  Fly  1199 VKISDFGMSRE---EEEYIVSDGMKQIPVKWTAPEALNFGK-YTSLCDVWSYGILMWEIFSKGDT 1259
            |||.|||::|:   ..:| |..|..::|:||.|||:: |.| |::..||||||:|:|||||.|.:
Human  1036 VKICDFGLARDIYKNPDY-VRKGDTRLPLKWMAPESI-FDKIYSTKSDVWSYGVLLWEIFSLGGS 1098

  Fly  1260 PYSGMTN-----SRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            ||.|:..     ||.||    |.||..|:.:..|:|::||.||..|.:.||.|.|:...:..|:
Human  1099 PYPGVQMDEDFCSRLRE----GMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	19/118 (16%)
		TyrKc	1063..1311	CDD:197581	104/329 (32%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/329 (31%)
FLT1	NP_002010.2	IG_like	143..219	CDD:214653
		IG_like	237..328	CDD:214653	10/42 (24%)
		Ig1_VEGFR_like	245..327	CDD:143219	10/41 (24%)
		Ig2_VEGFR-1	353..424	CDD:143326	20/79 (25%)
		IG	568..640	CDD:214652	13/116 (11%)
		IGc2	569..640	CDD:197706	13/115 (11%)
		I-set	661..748	CDD:254352	15/100 (15%)
		IGc2	676..738	CDD:197706	11/73 (15%)
		PTKc_VEGFR1	819..1157	CDD:271109	106/343 (31%)
		Pkinase_Tyr	827..1154	CDD:285015	104/332 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..982		0/41 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910