DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and FNBP1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_011516701.1	Gene:	FNBP1 / 23048	HGNCID:	17069	Length:	650	Species:	Homo sapiens

Alignment Length:	733	Identity:	134/733 - (18%)
Similarity:	253/733 - (34%)	Gaps:	259/733 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LDHQAKQFKFNAEQLEV---VCDKLTHLSQDKRKARKAYQEEHAK------IAARLNHLTD---- 131
            :|...|..||..|:.|:   ...:|.:||:..:..:.:.:||..|      ..:.||.:.|
Human    22 IDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQ 86

  Fly   132 -EVVRKKSEYQ------KHLEGYKALRTRFEENYIKAPSRSGRK-----------LDDVRDKYQK 178
             ||:.:....|      ::::..|..|        |:....|||           |:..:.::::
Human    87 HEVISENMASQIIVDLARYVQELKQER--------KSNFHDGRKAQQHIETCWKQLESSKRRFER 143

  Fly   179 ACRKLHLTHNEYV-----LSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYG 238
            .|::.......:.     :::|:| :|||           ..||:          .|..:.|:
Human   144 DCKEADRAQQYFEKMDADINVTKA-DVEK-----------ARQQA----------QIRHQMAE-- 184

  Fly   239 DLTADKYKEIQKRIDTVIGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTV 303
            |..|| |..|.::.:      :...||      |.|.  .|.:||
Human   185 DSKAD-YSSILQKFN------HEQHEY------YHTH--IPNIFQ-------------------- 214

  Fly   304 DNLTVDWLRNRLQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQ 368
                      ::||:|      :.:.::|.|.:...:.| :..:|.......:||....:|:
Human   215 ----------KIQEME------ERRIVRMGESMKTYAEV-DRQVIPIIGKCLDGIVKAAESI--- 259

  Fly   369 SKDLNALRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLT--LEQNFIENGYNNEQQRSNSTS 431
                    .|:...|.:::..|......|..|.     :|.|  :::...:|..:|    |....
Human   260 --------DQKNDSQLVIEAYKSGFEPPGDIEF-----EDYTQPMKRTVSDNSLSN----SRGEG 307

  Fly   432 SPGL-------GIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLG 489
            .|.|       |.:...:::..:::||         .|..||..|            .|.|.|..
Human   308 KPDLKFGGKSKGKLWPFIKKNKLMSLL---------TSPHQPPPP------------PPASASPS 351

  Fly   490 SLSVIRDGNGP-SPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRR-TQCSMLCLGED 552
            ::.     ||| ||.:.:...:||.          .|..||.........|:| ||  ..|..::
Human   352 AVP-----NGPQSPKQQKEPLSHRF----------NEFMTSKPKIHCFRSLKRGTQ--SFCFHKE 399

  Fly   553 EEPVVLASPAPLTQLTAAVLTNTNNNHIYA----DLELDKKKDTSPS------PECKGEQIQPKK 607
                              ::..|.....||    |..|..|...:|.      ||.:.:::|.|.
Human   400 ------------------LMKRTIGKPTYAFEARDYVLSLKLGATPEDFSNLPPEQRRKKLQQKV 446

  Fly   608 EQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVN-------AIESAEENHIQTR 665
            :::..||.:         .:|:.|.:.::.|..||.. |..|..:       ..::.|:..::|:
Human   447 DELNKEIQK---------EMDQRDAITKMKDVYLKNP-QMGDPASLDHKLAEVSQNIEKLRVETQ 501

  Fly   666 KL------------AKDP---------DSQTKRSSSSSSECR-SSKDTSHSKKRSLSFSQKSISN 708
            |.            |:..         |||...:.::.::.| ||.|.|:::::|.....|.::.
Human   502 KFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESSPDGSYTEEQSQESEMKVLAT 566

  Fly   709 IFSNLKEF-SKSPLVRMG 725
            .|.:  || .:.||..:|
Human   567 DFDD--EFDDEEPLPAIG 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	36/198 (18%)
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
FNBP1	XP_011516701.1	F-BAR_FBP17	5..257	CDD:153360	56/318 (18%)
		HR1_FBP17	435..511	CDD:212019	16/85 (19%)
		SH3_FBP17	582..637	CDD:213004	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910