DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and FGFR4

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001341913.1	Gene:	FGFR4 / 2264	HGNCID:	3691	Length:	802	Species:	Homo sapiens

Alignment Length:	358	Identity:	117/358 - (32%)
Similarity:	177/358 - (49%)	Gaps:	49/358 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1016 RFEGPPFASIQEL----IMHQYHSELPVTVKSGAILRRPV-------------------CRERWE 1057
            |...|| |::|:|    :..|:..|...:.||.:.|.|.|                   ....||
Human   398 RHPRPP-ATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWE 461

  Fly  1058 LSNDDVVLLERIGRGNFGDVYKAK---LKSTKLD----VAVKTCRMTLPDEQKRKFLQEGRILKQ 1115
            ...|.:||.:.:|.|.||.|.:|:   :...:.|    ||||..:....|:.....:.|..::|.
Human   462 FPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL 526

  Fly  1116 YD-HPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR--------------KNSNGLTTRQQMGM 1165
            .. |.||:.|:|:|.|:.|:.:::|....|:|..:||              ::|.|..:...:..
Human   527 IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVS 591

  Fly  1166 CR-DAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWT 1227
            |. ..|.||:||||:.||||||||||.||..::.:||:|||::|  ...:|.......::||||.
Human   592 CAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWM 656

  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292
            |||||....||...||||:|||:||||:.|.:||.|:........:..|:||..|...|.|:|.|
Human   657 APEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGL 721

  Fly  1293 MLQCWAADAESRPHFDEIYNVVDALILRLDNSH 1325
            |.:||.|....||.|.::...:|.::|.:...:
Human   722 MRECWHAAPSQRPTFKQLVEALDKVLLAVSEEY 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	8/26 (31%)
		TyrKc	1063..1311	CDD:197581	99/272 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/272 (36%)
FGFR4	NP_001341913.1	IGc2	50..107	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..148
		Ig	157..241	CDD:325142
		Ig3_FGFR-2	264..351	CDD:143266
		PKc_like	454..767	CDD:328722	104/301 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810