DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and FGFR2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006717771.1	Gene:	FGFR2 / 2263	HGNCID:	3689	Length:	839	Species:	Homo sapiens

Alignment Length:	444	Identity:	125/444 - (28%)
Similarity:	192/444 - (43%)	Gaps:	86/444 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   921 EEEDSASDDVLSMKDHC---YCVPSLAASISL-----STNRPLYEEE-WFHGVLPREEVVRLLN- 975
            |:|.:||.|.|.:..:|   :.:..:..::.|     :|.:|.:..: ..|.:..|..:.|.::
Human   386 EKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSA 450

  Fly   976 ------NDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYH 1034
                  |....|||.|.|                   :.:|.      :.|..|.:.|.
Human   451 ESSSSMNSNTPLVRITTR-------------------LSSTA------DTPMLAGVSEY------ 484

  Fly  1035 SELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-------VAVK 1092
             |||...|             ||...|.:.|.:.:|.|.||.|..|:......|       ||||
Human   485 -ELPEDPK-------------WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVK 535

  Fly  1093 TCRMTLPDEQKRKFLQEGRILKQY-DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN--- 1153
            ..:....::.....:.|..::|.. .|.||:.|:|.|.|..|:.:::|....|:|..|||..
Human   536 MLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 600

  Fly  1154 ------------SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGM 1206
                        ...:|.:..:......|.||.||.|:.||||||||||.||...:.:||:|||:
Human   601 GMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 665

  Fly  1207 SRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRA 1269
            :|:  ..:|.......::||||.|||||....||...||||:|:||||||:.|.:||.|:.....
Human   666 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 730

  Fly  1270 RERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            .:.:..|:||..|.:...|:|.:|..||.|....||.|.::...:|.::....|
Human   731 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	16/93 (17%)
		TyrKc	1063..1311	CDD:197581	93/272 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	92/272 (34%)
FGFR2	XP_006717771.1	Ig1_FGFR	66..143	CDD:143174
		IG_like	66..143	CDD:214653
		Ig2_FGFR	183..267	CDD:143265
		IG_like	282..376	CDD:214653
		Ig3_FGFR	290..377	CDD:143175
		PTKc_FGFR2	474..786	CDD:270679	105/331 (32%)
		Pkinase_Tyr	499..775	CDD:285015	93/275 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810