DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Yes1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001192061.1	Gene:	Yes1 / 22612	MGIID:	99147	Length:	541	Species:	Mus musculus

Alignment Length:	403	Identity:	141/403 - (34%)
Similarity:	212/403 - (52%)	Gaps:	46/403 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   938 YCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGD----FLVRETIRNEESQIVLSVC 998
            |.||  |.||.        .|||:.|.:.|::..|||.|.|:    |||||:...:.:..:....
Mouse   144 YVVP--ADSIQ--------AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRD 198

  Fly   999 W-----NGHKHFIVQTTGEGNFRF-EGPPFASIQELIMH-QYHSE--------LPVTVKSGAILR 1048
            |     :..||:.::....|.:.. ....|.::|:|:.| ..|::        :..|||...
Mouse   199 WDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQT--- 260

  Fly  1049 RPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCR--MTLPDEQKRKFLQEGR 1111
            :.:.::.||:..:.:.|..::|:|.||:|:......| ..||:||.:  ..:|:    .||||.:
Mouse   261 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMMPE----AFLQEAQ 320

  Fly  1112 ILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG--LTTRQQMGMCRDAAAGMR 1174
            |:|:..|..:|.|..: |.::||.||.|.:..||||.:| |..:|  |...|.:.|....|.||.
Mouse   321 IMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSLLDFL-KEGDGKYLKLPQLVDMAAQIADGMA 383

  Fly  1175 YLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKY 1237
            |:|..|.|||||.|.|.||......||:|||::|  |:.||....|.| .|:|||||||..:|::
Mouse   384 YIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRF 447

  Fly  1238 TSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAE 1302
            |...||||:|||..|:.:||..||.||.|....|:::.|||||.|:..||.::.||..||..|.:
Mouse   448 TIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPD 512

  Fly  1303 SRPHFDEIYNVVD 1315
            .||.|:.|.:.::
Mouse   513 ERPTFEYIQSFLE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	24/104 (23%)
		TyrKc	1063..1311	CDD:197581	105/253 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/253 (42%)
Yes1	NP_001192061.1	SH3_Yes	92..149	CDD:212940	3/6 (50%)
		SH2_Src_family	152..251	CDD:199827	24/106 (23%)
		PTKc_Yes	262..540	CDD:270654	108/272 (40%)
		Pkinase_Tyr	275..524	CDD:285015	106/256 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910