DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and FGFR1

DIOPT Version :10

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_001167538.1 Gene:FGFR1 / 2260 HGNCID:3688 Length:853 Species:Homo sapiens


Alignment Length:831 Identity:201/831 - (24%)
Similarity:315/831 - (37%) Gaps:193/831 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   594 PSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAI---- 654
            |||... ||.||....:.:|.....|                  .|.|:...:..|||.:|    
Human    56 PSPTLP-EQAQPWGAPVEVESFLVHP------------------GDLLQLRCRLRDDVQSINWLR 101

  Fly   655 ---ESAEENHIQTRKLAKDPDSQ-------------TKRSSSS--------------SSECRSSK 689
               :.||.|  :||...::.:.|             |...|.|              |||.....
Human   102 DGVQLAESN--RTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDD 164

  Fly   690 DTSHSKKRSLSFSQKSISNIFSN-LKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCP 753
            |.|.|:       :|...|...| :..:..||.....|.|.:...:..|...|     |||:..|
Human   165 DDSSSE-------EKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP-----SSGTPNP 217

  Fly   754 TNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKS 818
            |.....:......:..........|:.|.|:.|.:           ||.:.:....    ::.:.
Human   218 TLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVV-----------PSDKGNYTCI----VENEY 267

  Fly   819 KAIRNTFRSKLLNFQLKRS--KPCKQC--TKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNC 879
            .:|.:|::..:    ::||  :|..|.  ...:.:....:|....|.:...||..........|.
Human   268 GSINHTYQLDV----VERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNG 328

  Fly   880 PPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDID-NDEEEEDSASDDVLSMKDHCYCVPSL 943
            ...|...: |.|||.  |.....::..|::....|::. .|..|....:.:.:.:..|...:..|
Human   329 SKIGPDNL-PYVQIL--KTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 390

  Fly   944 AA-----SISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHK 1003
            .|     ::..|   |||.|             .::...|.||:        |.:|.||      
Human   391 EALEERPAVMTS---PLYLE-------------IIIYCTGAFLI--------SCMVGSV------ 425

  Fly  1004 HFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELP----VTV--------KSGAILRRPVCRE-- 1054
              ||.....|..:.:   |.|  ::.:|:....:|    |||        .||.:|.||....  
Human   426 --IVYKMKSGTKKSD---FHS--QMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSS 483

  Fly  1055 -----------------RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKTCR 1095
                             ||||..|.:||.:.:|.|.||.|..|:......|       ||||..:
Human   484 GTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK 548

  Fly  1096 MTLPDEQKRKFLQEGRILKQY-DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN------ 1153
            ....::.....:.|..::|.. .|.||:.|:|.|.|..|:.:::|....|:|..||:..      
Human   549 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE 613

  Fly  1154 ---------SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE 1209
                     ...|:::..:......|.||.||.||.||||||||||.||..::.:||:|||::|:
Human   614 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 678

  Fly  1210 --EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARER 1272
              ..:|.......::||||.|||||....||...||||:|:|:||||:.|.:||.|:......:.
Human   679 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKL 743

  Fly  1273 IDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            :..|:||..|.:...|:|.:|..||.|....||.|.::...:|.::....|
Human   744 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN 794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 18/89 (20%)
PTKc_Fes_like 1067..1315 CDD:270637 91/272 (33%)
FGFR1NP_001167538.1 IgI_1_FGFR 58..151 CDD:409362 22/113 (19%)
Ig strand A 58..61 CDD:409362 1/2 (50%)
Ig strand A' 73..79 CDD:409362 1/5 (20%)
Ig strand B 82..92 CDD:409362 2/9 (22%)
Ig strand C 96..101 CDD:409362 1/4 (25%)
Ig strand C' 104..106 CDD:409362 0/1 (0%)
Ig strand D 111..115 CDD:409362 2/3 (67%)
Ig strand E 118..123 CDD:409362 0/4 (0%)
Ig strand F 129..138 CDD:409362 1/8 (13%)
Ig strand G 141..151 CDD:409362 1/9 (11%)
IgI_2_FGFR 184..278 CDD:409443 19/113 (17%)
Ig strand A 184..187 CDD:409443 0/2 (0%)
Ig strand A' 195..200 CDD:409443 2/4 (50%)
Ig strand B 204..212 CDD:409443 2/12 (17%)
Ig strand C 218..223 CDD:409443 1/4 (25%)
Ig strand C' 226..228 CDD:409443 0/1 (0%)
Ig strand D 237..240 CDD:409443 0/2 (0%)
Ig strand E 244..249 CDD:409443 2/4 (50%)
Ig strand F 258..265 CDD:409443 0/10 (0%)
Ig strand G 268..278 CDD:409443 2/9 (22%)
Ig 286..390 CDD:472250 18/106 (17%)
Ig strand B 304..308 CDD:409353 1/3 (33%)
Ig strand C 317..321 CDD:409353 0/3 (0%)
Ig strand E 355..359 CDD:409353 0/3 (0%)
Ig strand F 369..374 CDD:409353 1/4 (25%)
Ig strand G 382..385 CDD:409353 1/2 (50%)
PTKc_FGFR1 495..796 CDD:270678 100/300 (33%)
Blue background indicates that the domain is not in the aligned region.

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