DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and FGFR1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_011542745.1	Gene:	FGFR1 / 2260	HGNCID:	3688	Length:	865	Species:	Homo sapiens

Alignment Length:	833	Identity:	201/833 - (24%)
Similarity:	315/833 - (37%)	Gaps:	195/833 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 PSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAI---- 654
            |||... ||.||....:.:|.....|                  .|.|:...:..|||.:|
Human    56 PSPTLP-EQAQPWGAPVEVESFLVHP------------------GDLLQLRCRLRDDVQSINWLR 101

  Fly   655 ---ESAEENHIQTRKLAKDPDSQ-------------TKRSSSS--------------SSECRSSK 689
               :.||.|  :||...::.:.|             |...|.|              |||.....
Human   102 DGVQLAESN--RTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDD 164

  Fly   690 DTSHSKKRSLSFSQKSISNIFSN---LKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSD 751
            |.|.|:       :|...|...|   :..:..||.....|.|.:...:..|...|     |||:.
Human   165 DDSSSE-------EKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP-----SSGTP 217

  Fly   752 CPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQK 816
            .||.....:......:..........|:.|.|:.|.:           ||.:.:....    ::.
Human   218 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVV-----------PSDKGNYTCI----VEN 267

  Fly   817 KSKAIRNTFRSKLLNFQLKRS--KPCKQC--TKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFC 877
            :..:|.:|::..:    ::||  :|..|.  ...:.:....:|....|.:...||..........
Human   268 EYGSINHTYQLDV----VERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV 328

  Fly   878 NCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDID-NDEEEEDSASDDVLSMKDHCYCVP 941
            |....|...: |.|||.  |.....::..|::....|::. .|..|....:.:.:.:..|...:.
Human   329 NGSKIGPDNL-PYVQIL--KTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLT 390

  Fly   942 SLAA-----SISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNG 1001
            .|.|     ::..|   |||.|             .::...|.||:        |.:|.||
Human   391 VLEALEERPAVMTS---PLYLE-------------IIIYCTGAFLI--------SCMVGSV---- 427

  Fly  1002 HKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELP----VTV--------KSGAILRRPVCRE 1054
                ||.....|..:.:   |.|  ::.:|:....:|    |||        .||.:|.||....
Human   428 ----IVYKMKSGTKKSD---FHS--QMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLS 483

  Fly  1055 -------------------RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKT 1093
                               ||||..|.:||.:.:|.|.||.|..|:......|       ||||.
Human   484 SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKM 548

  Fly  1094 CRMTLPDEQKRKFLQEGRILKQY-DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN---- 1153
            .:....::.....:.|..::|.. .|.||:.|:|.|.|..|:.:::|....|:|..||:..
Human   549 LKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 613

  Fly  1154 -----------SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMS 1207
                       ...|:::..:......|.||.||.||.||||||||||.||..::.:||:|||::
Human   614 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 678

  Fly  1208 RE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRAR 1270
            |:  ..:|.......::||||.|||||....||...||||:|:|:||||:.|.:||.|:......
Human   679 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 743

  Fly  1271 ERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            :.:..|:||..|.:...|:|.:|..||.|....||.|.::...:|.::....|
Human   744 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/89 (20%)
		TyrKc	1063..1311	CDD:197581	93/272 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/272 (33%)
FGFR1	XP_011542745.1	Ig1_FGFR	73..151	CDD:143174	17/97 (18%)
		IG_like	77..151	CDD:214653	16/93 (17%)
		I-set	193..280	CDD:254352	17/106 (16%)
		Ig2_FGFR	196..280	CDD:143265	17/103 (17%)
		IG_like	295..391	CDD:214653	16/98 (16%)
		Ig3_FGFR	303..392	CDD:143175	16/91 (18%)
		PTKc_FGFR1	497..797	CDD:270678	100/300 (33%)
		Pkinase_Tyr	511..787	CDD:285015	93/275 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810