| Sequence 1: | NP_524288.3 | Gene: | FER / 41118 | FlyBaseID: | FBgn0000723 | Length: | 1325 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001996.1 | Gene: | FES / 2242 | HGNCID: | 3657 | Length: | 822 | Species: | Homo sapiens |
| Alignment Length: | 1332 | Identity: | 344/1332 - (25%) |
|---|---|---|---|
| Similarity: | 501/1332 - (37%) | Gaps: | 530/1332 - (39%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYA-----ISLTAVAQQGLKIDR 60
Fly 61 ADEMQGSLISKSWRSYMDELDHQAKQFKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAA 124
Fly 125 RLNHLTDEVVRK-KSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHN 188
Fly 189 EYVLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRID 253
Fly 254 TVIGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQD----IPGKLQSSTLTVDNLTVDWLRNR 314
Fly 315 LQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQE 379
Fly 380 KQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELM-R 443
Fly 444 RGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPI 508
Fly 509 TNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLT 573
Fly 574 NTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLD 638
Fly 639 DRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQ 703
Fly 704 KSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNK 768
Fly 769 NTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQ 833
Fly 834 LKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKD 898
Fly 899 HPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHG 963
Fly 964 VLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNG-HKHFIVQTTGEGNFRFEGPPFASIQE 1027
Fly 1028 LIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVK 1092
Fly 1093 TCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGL 1157
Fly 1158 TTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE--YIVSDGMK 1220
Fly 1221 QIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKST 1285
Fly 1286 PEEMYRLMLQCWAADAESRPHFDEIYNVVDAL 1317 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FER | NP_524288.3 | F-BAR_Fes_Fer | 7..243 | CDD:153341 | 67/242 (28%) |
| SH2_Fps_family | 953..1039 | CDD:198224 | 39/86 (45%) | ||
| TyrKc | 1063..1311 | CDD:197581 | 146/249 (59%) | ||
| PTKc_Fes_like | 1067..1315 | CDD:270637 | 146/249 (59%) | ||
| FES | NP_001996.1 | Important for interaction with membranes containing phosphoinositides | 1..300 | 90/309 (29%) | |
| F-BAR_Fes | 7..239 | CDD:153369 | 67/242 (28%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 394..421 | 14/87 (16%) | |||
| SH2_Fps_family | 453..537 | CDD:198224 | 39/86 (45%) | ||
| Pkinase_Tyr | 561..814 | CDD:285015 | 148/252 (59%) | ||
| PTKc_Fes | 564..815 | CDD:270667 | 146/250 (58%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 310 | 1.000 | Domainoid score | I1327 |
| eggNOG | 1 | 0.900 | - | - | E2759_KOG0194 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 552 | 1.000 | Inparanoid score | I1129 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D255116at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000006 | |
| OrthoInspector | 1 | 1.000 | - | - | otm42064 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100013 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR24418 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3894 |
| SonicParanoid | 1 | 1.000 | - | - | X1749 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 13 | 12.860 | |||||