DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and FER

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:XP_011541568.1 Gene:FER / 2241 HGNCID:3655 Length:837 Species:Homo sapiens


Alignment Length:1333 Identity:339/1333 - (25%)
Similarity:518/1333 - (38%) Gaps:531/1333 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQGLKIDRADEMQ 65
            |||.|.|::  :|||::..||.||||:||:|:.:.::.|.|||||.:|..:..|   :|:...:|
Human     1 MGFGSDLKN--SHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQ---VDKESTVQ 60

  Fly    66 ---GSLISKSWRSYMDELDHQAKQFKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAARL 126
               .|.:||||...:.:.:..::..|.:||.|.. ...:||.:.:||::.:|:|...|.:|.|.:
Human    61 MNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEM 125

  Fly   127 NHLT-DEVVRKKSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHNEY 190
            ..:| .|:.:.|..|::.::...:.:.:::|...|     |::.:..:::|.||..|||:.||:|
Human   126 IKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAK-----GKETEKAKERYDKATMKLHMLHNQY 185

  Fly   191 VLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRIDTV 255
            ||::..|...:..:.::.||.||:..|.:||..|...:.|..|.:|...|..::...:.|.|...
Human   186 VLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMS 250

  Fly   256 IGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEG 320
            :..|:|:.||..|.:.::|:.......:||.:|::: ...||::.:..:|||.:.|:..|:.|..
Human   251 VEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEE-NENLQANEIMWNNLTAESLQVMLKTLAE 314

  Fly   321 AVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQEKQKQKL 385
            .:...|:..:...|.|               ......|:.:.:: |.:..|:..|.   .|||.|
Human   315 ELMQTQQMLLNKEEAV---------------LELEKRIEESSET-CEKKSDIVLLL---SQKQAL 360

  Fly   386 VDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTL 450
             :.:|.::.::.|.|.......:| |||...||                                
Human   361 -EELKQSVQQLRCTEAKFSAQKEL-LEQKVQEN-------------------------------- 391

  Fly   451 LRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQ 515
                                                         ||..|.|.            
Human   392 ---------------------------------------------DGKEPPPV------------ 399

  Fly   516 AASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHI 580
               |:|  ||.|.|.|:                                                
Human   400 ---VNY--EEDARSVTS------------------------------------------------ 411

  Fly   581 YADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTL 645
                 :::|:..|            |.|.||                                  
Human   412 -----MERKERLS------------KFESIR---------------------------------- 425

  Fly   646 QPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIF 710
                                                                      .||:.|.
Human   426 ----------------------------------------------------------HSIAGII 432

  Fly   711 SNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSN 775
                   :||...:|                                                  
Human   433 -------RSPKSALG-------------------------------------------------- 440

  Fly   776 HSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPC 840
                                                                             
Human   441 ----------------------------------------------------------------- 440

  Fly   841 KQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSS 905
                                                                             
Human   441 ----------------------------------------------------------------- 440

  Fly   906 GELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEV 970
                              .||..|::|:.:                 :||.|::|:||.:||.|.
Human   441 ------------------SSALSDMISISE-----------------KPLAEQDWYHGAIPRIEA 470

  Fly   971 VRLLNNDGDFLVRETIRNEESQIVLSVCWNG-HKHFIVQTTGEGNFRFEGPPFASIQELIMHQYH 1034
            ..||...|||||||: ..:..:.||||..:| .:|||:|.. :..:||||..|::|.:||.|.|.
Human   471 QELLKKQGDFLVRES-HGKPGEYVLSVYSDGQRRHFIIQYV-DNMYRFEGTGFSNIPQLIDHHYT 533

  Fly  1035 SELPVTVKSGAILRRPVCRE-RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTL 1098
            ::..:|.|||.:|..|:.:: :|.||::||:|.|.:|:||||:|||..||. |..||||||:..|
Human   534 TKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKD-KTSVAVKTCKEDL 597

  Fly  1099 PDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQM 1163
            |.|.|.|||||.:|||||||||||||||:|.|:||:.|:||||.||..||:||:..:.|..:|.:
Human   598 PQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLV 662

  Fly  1164 GMCRDAAAGMRYLESKNCIHR---------------DLAARNCLVDLEHSVKISDFGMSREEEEY 1213
            ....||||||.||||||||||               |||||||||...:.:|||||||||:|:..
Human   663 KFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLGDLAARNCLVGENNVLKISDFGMSRQEDGG 727

  Fly  1214 IV-SDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY 1277
            :. |.|:||||:|||||||||:|:|:|..||||:|||:||.||.|..||.||||.:|||:::.||
Human   728 VYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGY 792

  Fly  1278 RMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            ||..|:..||::.::|::||....|:||.|.|:
Human   793 RMSAPQHCPEDISKIMMKCWDYKPENRPKFSEL 825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341 72/240 (30%)
SH2_Fps_family 953..1039 CDD:198224 37/86 (43%)
TyrKc 1063..1311 CDD:197581 150/264 (57%)
PTKc_Fes_like 1067..1315 CDD:270637 148/260 (57%)
FERXP_011541568.1 F-BAR_Fer 5..238 CDD:153370 72/237 (30%)
SH2_Fps_family 453..538 CDD:198224 11/84 (13%)
Pkinase_Tyr 563..829 CDD:285015 12/265 (5%)
PKc_like 566..831 CDD:304357 12/264 (5%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 310 1.000 Domainoid score I1327
eggNOG 1 0.900 - - E2759_KOG0194
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H74300
Inparanoid 1 1.050 552 1.000 Inparanoid score I1129
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D255116at33208
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 1 1.000 - - otm42064
orthoMCL 1 0.900 - - OOG6_100013
Panther 1 1.100 - - O PTHR24418
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3894
SonicParanoid 1 1.000 - - X1749
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.860

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