Protein Alignment FER and Txk

DIOPT Version :10

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_036020891.1
• Gene: Txk / 22165
• MGIID: 102960
• Length: 543
• Species: Mus musculus
• Alignment Length: 592
• Identity: 176/592 - (29%)
• Similarity: 266/592 - (44%)
• Gaps: 137/592 - (23%)

  Fly   774 SNHSASQSTII-----TSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQ 833
            |::|:.||.:.     .|.....:.|..:.:..:|.|         :|.|:..|..| :||:.
Mouse    33 SSYSSFQSVLCCCCCRCSVQKRQVRTQISLSREEELS---------EKHSQRQRPWF-AKLMG-- 85

  Fly   834 LKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKD 898
                   |..:.|..:.|||           .:|           .||..|:|....:|:....|
Mouse    86 -------KTQSNRGGVQPSK-----------RKP-----------LPPLPQEPPDERIQVKALYD 121

  Fly   899 H-PFESSSGELD--------ENSD------RDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASIS 948
            . |.|..:..|.        |..|      ||...:|.                 .:||...:.:
Mouse   122 FLPREPGNLALKRAEEYLILERCDPHWWKARDRFGNEG-----------------LIPSNYVTEN 169

  Fly   949 LSTNRPLYEEEWFHGVLPREEVVRLLN---NDGDFLVRE-------TI-------RNEESQIVLS 996
            ...|..:|  ||:|..:.|.:..|||.   .:|.|:||:       ||       |:.:|.|
Mouse   170 RLANLEIY--EWYHKNITRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSI--- 229

  Fly   997 VCWNGHKHFIVQTTGEGNFRF-EGPPFASIQELIM-HQYHSELPVTVKSGAI--LRRPV-----C 1052
                  ||:.::....|.:.. |...|.|:.|||. |||::       :|.|  ||.|:     |
Mouse   230 ------KHYQIKKNDSGQWYITERHLFPSVPELIQYHQYNA-------AGLISRLRYPIGLLGSC 281

  Fly  1053 --------RERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQE 1109
                    .|:||:...::..::.||.|.||.|:..:.:: .:.||:|........|:  .|::|
Mouse   282 LPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRA-HIPVAIKAINEGSMSEE--DFIEE 343

  Fly  1110 GRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMR 1174
            .:::.:..|..:|:|.|:|:|::|:.||.|.:..|.||.|||:....|.....:.||:|...||.
Mouse   344 AKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMA 408

  Fly  1175 YLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKY 1237
            |||....||||||||||||.....||||||||:|.  ::|||.|.|.| .||||..||..:|.||
Mouse   409 YLERSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAK-FPVKWCPPEVFHFNKY 472

  Fly  1238 TSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAE 1302
            :|..||||:|:||||:|::|..|:...:|.:..|.|..|:|:..|...|..:||:|..|| .:..
Mouse   473 SSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCW-HETL 536

  Fly  1303 SRPHFDE 1309
            .:|.|.|
Mouse   537 QKPVFQE 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	29/104 (28%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/245 (41%)
Txk	XP_036020891.1	SH3_TXK	114..168	CDD:212840	12/70 (17%)
		SH2_Tec_Txk	172..277	CDD:198261	35/122 (29%)
		Protein Kinases, catalytic domain	295..543	CDD:473864	100/252 (40%)