DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and PTK2B

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_004094.3	Gene:	PTK2B / 2185	HGNCID:	9612	Length:	1009	Species:	Homo sapiens

Alignment Length:	282	Identity:	111/282 - (39%)
Similarity:	163/282 - (57%)	Gaps:	13/282 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly  1034 HSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYK---AKLKSTKLDVAVKTCR 1095
            ::|:|     ...|||| ...::.::.:||||...:|.|.||:||:   ...|..|::||||||:
Human   402 YAEIP-----DETLRRP-GGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCK 460

  Fly  1096 MTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTR 1160
            .....:.|.||:.|..|:|..|||:||||||| ::::|..|:|||...|.|..||.:|.|.|...
Human   461 KDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGI-IEEEPTWIIMELYPYGELGHYLERNKNSLKVL 524

  Fly  1161 QQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIP 1223
            ..:.........|.||||.||:|||:|.||.||.....||:.|||:||  |:|:|..: .:.::|
Human   525 TLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKA-SVTRLP 588

  Fly  1224 VKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEE 1288
            :||.:||::||.::|:..|||.:.:.||||.|.|..|:..:.|......::.|.|:|.|...|..
Human   589 IKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPV 653

  Fly  1289 MYRLMLQCWAADAESRPHFDEI 1310
            :|.||.:||..|...||.|.|:
Human   654 LYTLMTRCWDYDPSDRPRFTEL 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	1/4 (25%)
		TyrKc	1063..1311	CDD:197581	104/253 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/249 (41%)
PTK2B	NP_004094.3	B41	41..254	CDD:214604
		FERM_B-lobe	150..254	CDD:271216
		FERM_C_FAK1	261..368	CDD:270011
		PTKc_FAK	418..687	CDD:133187	105/260 (40%)
		TyrKc	425..679	CDD:197581	104/253 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..725
		Interaction with TGFB1I1. /evidence=ECO:0000250	801..1009
		Focal adhesion targeting (FAT)	868..1009
		Focal_AT	872..1001	CDD:281606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910