DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Tec

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001106931.1	Gene:	Tec / 21682	MGIID:	98662	Length:	630	Species:	Mus musculus

Alignment Length:	405	Identity:	131/405 - (32%)
Similarity:	215/405 - (53%)	Gaps:	36/405 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   940 VPSLAASISLSTNRPLYEEEWFHGVLPR---EEVVRLLNNDGDFLVRETIRNEESQIVLSVCW-- 999
            :||...:...|.|...|  ||:.....|   |:::|..:.:|.|:||::.:.....:.|...:
Mouse   228 IPSNYVTGKKSNNLDQY--EWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGG 290

  Fly  1000 ---NGHKHFIVQTTGEGNFRF---EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCR----- 1053
               :|.:|:.::.|.....::   |...|.||.|:|.:..|:...:..:    ||.||..
Mouse   291 EGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTR----LRYPVSTKGKNA 351

  Fly  1054 --------ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEG 1110
                    ::||::..::..:..:|.|.||.|...|.:: :..||:|..|.....|:  .|::|.
Mouse   352 PTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEE--DFIEEA 413

  Fly  1111 RILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRY 1175
            :::.:..||.:|:|.|:|.|::||.||.|.:..|.||.:||:.....:....:.||:|...||.|
Mouse   414 KVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDMLLSMCQDVCEGMEY 478

  Fly  1176 LESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYT 1238
            ||..:.||||||||||||:....||:|||||:|.  :::|..|.|.| .||||..||..|:.:::
Mouse   479 LERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAK-FPVKWCPPEVFNYSRFS 542

  Fly  1239 SLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAES 1303
            |..||||:|:||||||::|..|:...||......:..|:|:..||...:.:|.:||:||....|.
Mouse   543 SKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQERPEG 607

  Fly  1304 RPHFDEIYNVVDALI 1318
            ||.|:::...:|.|:
Mouse   608 RPSFEDLLRTIDELV 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	21/96 (22%)
		TyrKc	1063..1311	CDD:197581	98/249 (39%)
		PTKc_Fes_like	1067..1315	CDD:270637	98/249 (39%)
Tec	NP_001106931.1	PH_Btk	7..148	CDD:269944
		SH3_Tec	182..236	CDD:212838	2/7 (29%)
		SH2_Tec_Itk	239..346	CDD:198259	26/112 (23%)
		PTKc_Tec_Rlk	364..623	CDD:270685	100/263 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910