DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Srms

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_035611.3	Gene:	Srms / 20811	MGIID:	101865	Length:	507	Species:	Mus musculus

Alignment Length:	480	Identity:	149/480 - (31%)
Similarity:	230/480 - (47%)	Gaps:	69/480 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   892 QISGHKDHPFESSSGELDENS-------------DRDIDNDEEEEDSASDDVLSMK---DHCYC- 939
            :|.||.|:|....:..::..|             |......||...|..|.:.::|   |:.:.
Mouse    42 RIQGHDDNPVPEQAAAVEPCSFPAPRARLFRALYDFTARCAEELSVSRGDRLYALKEEGDYIFAQ 106

  Fly   940 ----------VPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEE 990
                      ||  ...::.:|..|..::.|:...:.|.:..:||    |..|.||:|.:    |
Mouse   107 RLSGPPSTGLVP--VTYLAKATPEPPSDQPWYFSGISRAQAQQLLLSPANAPGAFLIRPS----E 165

  Fly   991 SQI---------VLSVCWNGHKHFIVQTTGEGN-FRFEGPPFASIQELIMHQYHSE---LPVTVK 1042
            |.|         ...||     |:.:.....|: :..||..|.|:..|:.: |.:.   :...:.
Mouse   166 SSIGGYSLSVRAQAKVC-----HYRICMAPSGSLYLQEGQLFPSLDALLAY-YKTNWKLIQNPLL 224

  Fly  1043 SGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCR---MTLPDEQKR 1104
            ...|.:.|:.::.||....:.||..::|.|.||:|::. |....:.||||..:   |.|.|..|
Mouse   225 QPCIPQIPLVQDEWERPRSEFVLRRKLGEGFFGEVWEG-LWLGSIPVAVKVIKSADMKLADLTK- 287

  Fly  1105 KFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYL-RKNSNGLTTRQQMGMCRD 1168
                |...||...|..:::|..||...:|:.||.||:..|:|..|| ......|:....:|....
Mouse   288 ----EIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLGFACQ 348

  Fly  1169 AAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEA 1231
            .|.||.|||.:..:||||||||.||..:.:.|::|||::|  :::.|..|.|.| ||||||||||
Mouse   349 VAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSK-IPVKWTAPEA 412

  Fly  1232 LNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQC 1296
            .|:..::...||||:|||::|:|:.|..||.||||....::|..|||:|.|...|.|:|.||::|
Mouse   413 ANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRPAVCPAEVYVLMVEC 477

  Fly  1297 WAADAESRPHFDEIYNVVDALILRL 1321
            |....|.||.|..:...::|:..||
Mouse   478 WKGSPEERPTFAILREKLNAINRRL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/102 (23%)
		TyrKc	1063..1311	CDD:197581	103/253 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/253 (40%)
Srms	NP_035611.3	SH3	70..124	CDD:302595	9/55 (16%)
		SH2_Srm	134..212	CDD:198223	21/87 (24%)
		PTKc_Srm_Brk	238..498	CDD:133248	105/266 (39%)
		STYKc	246..495	CDD:214568	103/255 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910