DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Src

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006499126.1	Gene:	Src / 20779	MGIID:	98397	Length:	552	Species:	Mus musculus

Alignment Length:	562	Identity:	171/562 - (30%)
Similarity:	252/562 - (44%)	Gaps:	126/562 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   836 RSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKD-- 898
            :|||.....:||.:.||::|          ..||.|.        ||.|.|.||: ...||:.
Mouse     5 KSKPKDASQRRRSLEPSENV----------HGAGGAF--------PASQTPSKPA-SADGHRGPS 50

  Fly   899 -----------------------------------------HPFESSSGELD-----------EN 911
                                                     :.:||.: |.|           .|
Mouse    51 AAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRT-ETDLSFKKGERLQIVN 114

  Fly   912 SDRDIDND---------EEEEDSASDDVLSMKDHCYCVPS--LAASISLSTNRPLYEEEWFHGVL 965
            :.|.:|..         :.|.|......||.....| :||  :|.|.|:..      |||:.|.:
Mouse   115 NTRKVDVSQTWFTFRWLQREGDWWLAHSLSTGQTGY-IPSNYVAPSDSIQA------EEWYFGKI 172

  Fly   966 PREEVVRLL----NNDGDFLVRETIRNEESQIVLSVCWNGH------KHFIVQTTGEGNFRFEG- 1019
            .|.|..|||    |..|.|||||: ...:....|||....:      ||:.::....|.|....
Mouse   173 TRRESERLLLNAENPRGTFLVRES-ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSR 236

  Fly  1020 PPFASIQELIMHQYHSE--------LPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGD 1076
            ..|.|:|:|:  .|:|:        |.....:.....:.:.::.||:..:.:.|..::|:|.||:
Mouse   237 TQFNSLQQLV--AYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGE 299

  Fly  1077 VYKAKLKSTKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMEL 1140
            |:......| ..||:||.:. |:..|   .||||.:::|:..|..:|:|..: |.::||.||.|.
Mouse   300 VWMGTWNGT-TRVAIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEY 359

  Fly  1141 VLGGSLLTYLRKNSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISD 1203
            :..||||.:| |...|  |...|.:.|....|:||.|:|..|.:||||.|.|.||......|::|
Mouse   360 MNKGSLLDFL-KGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVAD 423

  Fly  1204 FGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTN 1266
            ||::|  |:.||....|.| .|:|||||||..:|::|...||||:|||:.|:.:||..||.||.|
Mouse   424 FGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN 487

  Fly  1267 SRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFD 1308
            ....::::.|||||.|...||.::.||.|||..:.|.||.|:
Mouse   488 REVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/104 (29%)
		TyrKc	1063..1311	CDD:197581	103/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/247 (41%)
Src	XP_006499126.1	SH3_Src	87..159	CDD:212941	15/73 (21%)
		SH2_Src_Src	163..263	CDD:198228	30/108 (28%)
		PTKc_Src	276..552	CDD:270656	105/261 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910