DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and EPHB4

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_016867305.1	Gene:	EPHB4 / 2050	HGNCID:	3395	Length:	1005	Species:	Homo sapiens

Alignment Length:	332	Identity:	123/332 - (37%)
Similarity:	181/332 - (54%)	Gaps:	46/332 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1002 HKHFIVQTTGEGN------FRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSN 1060
            |..:::   |.|.      |.:|.|..|      :.::..|:.|:.
Human   596 HGQYLI---GHGTKVYIDPFTYEDPNEA------VREFAKEIDVSY------------------- 632

  Fly  1061 DDVVLLERIGRGNFGDVYKAKLKS---TKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIV 1122
              |.:.|.||.|.||:|.:.:||:   .:..||:||.:....:.|:|:||.|..|:.|::||||:
Human   633 --VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNII 695

  Fly  1123 KLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLA 1187
            :|.|:.....|:||:.|.:..|:|.::||.|....|..|.:||.|..|:|||||...:.:|||||
Human   696 RLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLA 760

  Fly  1188 ARNCLVDLEHSVKISDFGMSREEEE------YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSY 1246
            |||.||:.....|:||||:||..||      |..|.|.| ||::||||||:.|.|:||..|.|||
Human   761 ARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGK-IPIRWTAPEAIAFRKFTSASDAWSY 824

  Fly  1247 GILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIY 1311
            ||:|||:.|.|:.||..|:|......|:..||:|.|...|..:::|||.||..|..:||.|.::.
Human   825 GIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVV 889

  Fly  1312 NVVDALI 1318
            :.:|.:|
Human   890 SALDKMI 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	8/42 (19%)
		TyrKc	1063..1311	CDD:197581	112/256 (44%)
		PTKc_Fes_like	1067..1315	CDD:270637	111/256 (43%)
EPHB4	XP_016867305.1	EphR_LBD_B4	17..196	CDD:198442
		FN3	324..429	CDD:238020
		FN3	452..544	CDD:238020
		EphA2_TM	<582..628	CDD:291255	7/40 (18%)
		PTKc_EphR_B	628..896	CDD:173638	114/289 (39%)
		Pkinase_Tyr	633..892	CDD:285015	112/259 (43%)
		SAM	922..989	CDD:197735
		SAM_EPH-B4	925..991	CDD:188953
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910