DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and EPHB3

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_004434.2 Gene:EPHB3 / 2049 HGNCID:3394 Length:998 Species:Homo sapiens


Alignment Length:717 Identity:191/717 - (26%)
Similarity:288/717 - (40%) Gaps:227/717 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   733 EQDAKRTQ-----PSQHHHSSGS----DCPTNSSSSS-----SNNNNNNKNTSSNSNHSASQSTI 783
            |..||.:|     |..:....|.    .||.||.::|     ...:||.....|:|..||     
Human   276 EPAAKESQCRPCPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSA----- 335

  Fly   784 ITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKP--------- 839
                        .||.||....              .|.|...:.|:   |:.|:|         
Human   336 ------------CTTVPSPPRG--------------VISNVNETSLI---LEWSEPRDLGGRDDL 371

  Fly   840 -----CKQC------------------------TKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQ 875
                 ||:|                        ...||:|.|..:......|||:...|      
Human   372 LYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLAHTRYTFEVQAVNG------ 430

  Fly   876 FCNCPPAGQKPVKP---SVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHC 937
                 .:|:.|:.|   :|.|:.::..|.|..:..|..:|                         
Human   431 -----VSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSS------------------------- 465

  Fly   938 YCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGH 1002
                  .:|::||...|    |..:||:...|:.....::|   :..|:.::.:.:.|    :|.
Human   466 ------GSSLTLSWAPP----ERPNGVILDYEMKYFEKSEG---IASTVTSQMNSVQL----DGL 513

  Fly  1003 K---HFIVQ-----TTGEGNF----RFE-----GPPFASIQELIMHQYHSELPVTVKS------- 1043
            :   .::||     ..|.|.:    .||     |.....:||        :||:.|.|       
Human   514 RPDARYVVQVRARTVAGYGQYSRPAEFETTSERGSGAQQLQE--------QLPLIVGSATAGLVF 570

  Fly  1044 --GAILRRPVCRERWELSNDD-----------------------------------------VVL 1065
              ..::...||..:....:|.                                         |.:
Human   571 VVAVVVIAIVCLRKQRHGSDSEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREFAKEIDVSCVKI 635

  Fly  1066 LERIGRGNFGDVYKAKLKS---TKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGI 1127
            .|.||.|.||:|.:.:||.   .::.||:||.::...:.|:|.||.|..|:.|:|||||::|.|:
Human   636 EEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGV 700

  Fly  1128 CVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCL 1192
            ..:.:|:||:.|.:...:|.::||.|....|..|.:||.|..||||:||...|.:||||||||.|
Human   701 VTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 765

  Fly  1193 VDLEHSVKISDFGMSREEEE------YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMW 1251
            |:.....|:||||:||..|:      |..|.|.| ||::||||||:.:.|:||..|||||||:||
Human   766 VNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGK-IPIRWTAPEAIAYRKFTSASDVWSYGIVMW 829

  Fly  1252 EIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDA 1316
            |:.|.|:.||..|:|......::..||:|.|...|..:::|||.||..|...||.|.:|.|.:|.
Human   830 EVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDK 894

  Fly  1317 LI 1318
            ||
Human   895 LI 896

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 19/102 (19%)
TyrKc 1063..1311 CDD:197581 111/256 (43%)
PTKc_Fes_like 1067..1315 CDD:270637 112/256 (44%)
EPHB3NP_004434.2 EphR_LBD_B3 39..211 CDD:198446
Ephrin_rec_like <284..316 CDD:311571 7/31 (23%)
fn3 341..436 CDD:365830 19/122 (16%)
FN3 <473..542 CDD:238020 14/79 (18%)
EphA2_TM <581..628 CDD:373140 2/46 (4%)
PTKc_EphR_B 628..896 CDD:173638 114/268 (43%)
SAM_superfamily 922..990 CDD:387673
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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