DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and EPHB3

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_004434.2	Gene:	EPHB3 / 2049	HGNCID:	3394	Length:	998	Species:	Homo sapiens

Alignment Length:	717	Identity:	191/717 - (26%)
Similarity:	288/717 - (40%)	Gaps:	227/717 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   733 EQDAKRTQ-----PSQHHHSSGS----DCPTNSSSSS-----SNNNNNNKNTSSNSNHSASQSTI 783
            |..||.:|     |..:....|.    .||.||.::|     ...:||.....|:|..||
Human   276 EPAAKESQCRPCPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSA----- 335

  Fly   784 ITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKP--------- 839
                        .||.||....              .|.|...:.|:   |:.|:|
Human   336 ------------CTTVPSPPRG--------------VISNVNETSLI---LEWSEPRDLGGRDDL 371

  Fly   840 -----CKQC------------------------TKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQ 875
                 ||:|                        ...||:|.|..:......|||:...|
Human   372 LYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLAHTRYTFEVQAVNG------ 430

  Fly   876 FCNCPPAGQKPVKP---SVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHC 937
                 .:|:.|:.|   :|.|:.::..|.|..:..|..:|
Human   431 -----VSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSS------------------------- 465

  Fly   938 YCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGH 1002
                  .:|::||...|    |..:||:...|:.....::|   :..|:.::.:.:.|    :|.
Human   466 ------GSSLTLSWAPP----ERPNGVILDYEMKYFEKSEG---IASTVTSQMNSVQL----DGL 513

  Fly  1003 K---HFIVQ-----TTGEGNF----RFE-----GPPFASIQELIMHQYHSELPVTVKS------- 1043
            :   .::||     ..|.|.:    .||     |.....:||        :||:.|.|
Human   514 RPDARYVVQVRARTVAGYGQYSRPAEFETTSERGSGAQQLQE--------QLPLIVGSATAGLVF 570

  Fly  1044 --GAILRRPVCRERWELSNDD-----------------------------------------VVL 1065
              ..::...||..:....:|.                                         |.:
Human   571 VVAVVVIAIVCLRKQRHGSDSEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREFAKEIDVSCVKI 635

  Fly  1066 LERIGRGNFGDVYKAKLKS---TKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGI 1127
            .|.||.|.||:|.:.:||.   .::.||:||.::...:.|:|.||.|..|:.|:|||||::|.|:
Human   636 EEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGV 700

  Fly  1128 CVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCL 1192
            ..:.:|:||:.|.:...:|.::||.|....|..|.:||.|..||||:||...|.:||||||||.|
Human   701 VTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 765

  Fly  1193 VDLEHSVKISDFGMSREEEE------YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMW 1251
            |:.....|:||||:||..|:      |..|.|.| ||::||||||:.:.|:||..|||||||:||
Human   766 VNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGK-IPIRWTAPEAIAYRKFTSASDVWSYGIVMW 829

  Fly  1252 EIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDA 1316
            |:.|.|:.||..|:|......::..||:|.|...|..:::|||.||..|...||.|.:|.|.:|.
Human   830 EVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDK 894

  Fly  1317 LI 1318
            ||
Human   895 LI 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	19/102 (19%)
		TyrKc	1063..1311	CDD:197581	111/256 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	112/256 (44%)
EPHB3	NP_004434.2	EphR_LBD_B3	39..211	CDD:198446
		Ephrin_rec_like	<284..316	CDD:311571	7/31 (23%)
		fn3	341..436	CDD:365830	19/122 (16%)
		FN3	<473..542	CDD:238020	14/79 (18%)
		EphA2_TM	<581..628	CDD:373140	2/46 (4%)
		PTKc_EphR_B	628..896	CDD:173638	114/268 (43%)
		SAM_superfamily	922..990	CDD:387673
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910