DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and EPHA7

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_004431.1	Gene:	EPHA7 / 2045	HGNCID:	3390	Length:	998	Species:	Homo sapiens

Alignment Length:	776	Identity:	202/776 - (26%)
Similarity:	315/776 - (40%)	Gaps:	222/776 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   698 SLSFSQKSISNIFSNL---------KEFSKSPLVRMGKNHILNEEQDAKRTQPSQH--------- 744
            |:....|...:|..||         .|||.  ||.:....:.:.|::|:.. |..|
Human   197 SVKVYYKKCWSIIENLAIFPDTVTGSEFSS--LVEVRGTCVSSAEEEAENA-PRMHCSAEGEWLV 258

  Fly   745 -------------------------HHSSGSD-----CPTNSSSSSSNNN------------NNN 767
                                     :.||..|     |||:|.|....::            ::.
Human   259 PIGKCICKAGYQQKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDP 323

  Fly   768 KNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNF 832
            ...:.....||.|:.|.....|   |.:...:|..:|..               ||....::|
Human   324 PYVACTRPPSAPQNLIFNINQT---TVSLEWSPPADNGG---------------RNDVTYRIL-- 368

  Fly   833 QLKRSKPCKQCT-KRRRIHPSKSVFDFAKE---------------------FEVEQ--------- 866
                   ||:|: ::....|..|...:..:                     ||||.
Human   369 -------CKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSR 426

  Fly   867 ----------PAGSAADEQFCNCPPAGQKPVKPSVQISGHK-DHPFESSSGELDENSDRDIDNDE 920
                      ..|.||..|....  ..::.::.||::|..: :||    :|.:.|...:..:.|:
Human   427 SQRLFAAVSITTGQAAPSQVSGV--MKERVLQRSVELSWQEPEHP----NGVITEYEIKYYEKDQ 485

  Fly   921 EEEDSASDDVLSMKDHCYCVPSLAASISLSTNRP---------LYEEEWFHGVLPREEVVRLLNN 976
            .|...::            |.:.:.|.|::..:|         .:....:....||.:|..|...
Human   486 RERTYST------------VKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEA 538

  Fly   977 DGDFLVRETIRNEESQI----VLSVCWN------------GHKHF-IVQTTGEG------NFRFE 1018
            .|.......:.:|::.:    |::|...            |.:|. ..:...||      :|:|.
Human   539 TGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFP 603

  Fly  1019 G------PPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLER-IGRGNFGD 1076
            |      |.........:||:..||..:           |           :.:|| ||.|.||:
Human   604 GTKTYIDPETYEDPNRAVHQFAKELDAS-----------C-----------IKIERVIGAGEFGE 646

  Fly  1077 VYKAKLK-STKLDVAV--KTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVM 1138
            |...:|| ..|.||||  ||.::...::|:|.||.|..|:.|:||||:|.|.|:..:.:|:|||:
Human   647 VCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVI 711

  Fly  1139 ELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISD 1203
            |.:..|:|..:|||:....|..|.:||.|..|||||||.....:||||||||.||:.....|:||
Human   712 EFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSD 776

  Fly  1204 FGMSREEEE-----YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSG 1263
            ||:||..|:     |..:.|  :|||:||||||:.:.|:||..|||||||:|||:.|.|:.||..
Human   777 FGLSRVIEDDPEAVYTTTGG--KIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWD 839

  Fly  1264 MTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNS 1324
            |:|....:.|:.|||:|.|...|..:::|||.||..:...||.|::|..::|.:| |..||
Human   840 MSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMI-RNPNS 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	21/123 (17%)
		TyrKc	1063..1311	CDD:197581	116/256 (45%)
		PTKc_Fes_like	1067..1315	CDD:270637	117/256 (46%)
EPHA7	NP_004431.1	EphR_LBD_A7	30..206	CDD:198453	2/8 (25%)
		FN3	332..438	CDD:238020	20/132 (15%)
		FN3	443..534	CDD:238020	17/108 (16%)
		EphA2_TM	565..630	CDD:405290	12/64 (19%)
		PTKc_EphR_A	628..894	CDD:270651	120/289 (42%)
		SAM_EPH-A7	919..988	CDD:188947
		PDZ-binding. /evidence=ECO:0000255	996..998
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910