DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and EPHA4

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001291465.1	Gene:	EPHA4 / 2043	HGNCID:	3388	Length:	986	Species:	Homo sapiens

Alignment Length:	988	Identity:	245/988 - (24%)
Similarity:	381/988 - (38%)	Gaps:	256/988 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   466 PATPMT----RSRQGRFNKL-QPRSQSLGSLSVIRDGNGPSPAR-------YEPITNHRL----- 513
            ||..:|    ||.||....: .|.......:|::.:.|  :|.|       .||..|:.|
Human    27 PANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKN--TPIRTYQVCNVMEPSQNNWLRTDWI 89

  Fly   514 -RQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNN 577
             |:.|...|:  ||           :.....|:.|       |.|:.:            .....
Human    90 TREGAQRVYI--EI-----------KFTLRDCNSL-------PGVMGT------------CKETF 122

  Fly   578 NHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDD--- 639
            |..|.:.:.||::....:...|.:.|...:...:::|.            |||.:||..:.|
Human   123 NLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIG------------DRIMKLNTEIRDVGP 175

  Fly   640 -RLKRTLQPSDDVNAIESA-------EENHIQTRKLAKDPDSQTKRSSSSSSECRSS-KDTSHSK 695
             ..|.......||.|..:.       ::..:..|.||:.||:.|...:||..|.|.| .:.|..|
Human   176 LSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEK 240

  Fly   696 KRSLSFSQKS------ISNIFSNLKEFSKS---PLVRMGKNHILNEEQDAKRTQPSQHHHS---S 748
            .....:....      |.|...|.....:|   ...::|....|:.:....:..|  |.:|   .
Human   241 DVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPP--HSYSVWEG 303

  Fly   749 GSDCP-----------------TNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTI---- 792
            .:.|.                 |...|:..|..:|...||.|...|:.|:|.....|:..:
Human   304 ATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKK 368

  Fly   793 --------------------------TTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLN 831
                                      ||..:.|....::...|::..:...||...|..:|..:.
Human   369 CGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVT 433

  Fly   832 FQLKRSKP-------CKQCTK-------RRRIHPSKSVFDF-AKEFEVEQPAGS------AADEQ 875
            ....::.|       .|:.|:       .....|:..:.:: .|.:|.:|...|      ||.
Human   434 VTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAAR-- 496

  Fly   876 FCNCPPAGQKPVKPSV------QISGHKD--HPFESSSGELDENSDRDIDNDEEEEDSASDDVL- 931
              |....|..|:...|      ..:|:.|  .|.|.::..:   ..|.|.      |.|:..||
Human   497 --NTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTV---PSRIIG------DGANSTVLL 550

  Fly   932 -SMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVL 995
             |:......|..|.|:..:|..|..|.:       .::|.                 :||..:..
Human   551 VSVSGSVVLVVILIAAFVISRRRSKYSK-------AKQEA-----------------DEEKHLNQ 591

  Fly   996 SVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSN 1060
            .|           .|....|.:|.|..|      :.::..|:..:           |
Human   592 GV-----------RTYVDPFTYEDPNQA------VREFAKEIDAS-----------C-------- 620

  Fly  1061 DDVVLLER-IGRGNFGDVYKAKLK---STKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNI 1121
               :.:|: ||.|.||:|...:||   ..::.||:||.:....|:|:|.||.|..|:.|:|||||
Human   621 ---IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNI 682

  Fly  1122 VKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDL 1186
            :.|.|:..:.:|:||:.|.:..|||..:||||....|..|.:||.|...:||:||...:.:||||
Human   683 IHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDL 747

  Fly  1187 AARNCLVDLEHSVKISDFGMSR-----EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSY 1246
            ||||.||:.....|:|||||||     .|..|....|  :||::||||||:.:.|:||..|||||
Human   748 AARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGG--KIPIRWTAPEAIAYRKFTSASDVWSY 810

  Fly  1247 GILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIY 1311
            ||:|||:.|.|:.||..|:|....:.|:.|||:|.|...|..:::|||.||..:...||.|.:|.
Human   811 GIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIV 875

  Fly  1312 NVVDALILRLDNS 1324
            |::|.|| |..||
Human   876 NMLDKLI-RNPNS 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	12/85 (14%)
		TyrKc	1063..1311	CDD:197581	111/256 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	113/256 (44%)
EPHA4	NP_001291465.1	EphR_LBD_A4	30..203	CDD:198450	40/218 (18%)
		FN3	329..436	CDD:238020	18/106 (17%)
		FN3	441..532	CDD:238020	18/94 (19%)
		EphA2_TM	562..618	CDD:405290	15/96 (16%)
		PTKc_EphR_A	616..882	CDD:270651	115/289 (40%)
		SAM_EPH-A4	911..981	CDD:188944
		PDZ-binding. /evidence=ECO:0000255	984..986
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910