DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and EPHA3

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_005224.2 Gene:EPHA3 / 2042 HGNCID:3387 Length:983 Species:Homo sapiens


Alignment Length:670 Identity:184/670 - (27%)
Similarity:283/670 - (42%) Gaps:180/670 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   752 CPTNSSSSSSNNNN----NN-----KNTSSNS-NHSASQSTIITSTITTTITTTTTTTPSKENSR 806
            ||.:||:....:.|    ||     |:..|.: ....|....:.|.|..|......:.|.....|
Human   290 CPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGR 354

  Fly   807 LKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSK--------SVFDFAKE-- 861
                        |.:......|...:.:|:   |:.|:...|..|.:        :|.|....  
Human   355 ------------KDVTFNIICKKCGWNIKQ---CEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTN 404

  Fly   862 --FEVEQPAG----SAADEQFC----NCPPAGQKPV---------KPSVQISGHK-DHPFESSSG 906
              ||::...|    |:...||.    ....|...||         :.|:.:|..: :||    :|
Human   405 YTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHP----NG 465

  Fly   907 ELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSL------------AASISLSTNRPLYEEE 959
            .:   .|.::...|::|...|..:|..:.....:.||            ..:....||...:|.|
Human   466 II---LDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFE 527

  Fly   960 WFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVL---------------------SVCWNGHK 1003
                           .:...|    :|..|.||:|:                     ..|  |:|
Human   528 ---------------TSPDSF----SISGESSQVVMIAISAAVAIILLTVVIYVLIGRFC--GYK 571

  Fly  1004 ----------HFIVQTTGEGNFR------------FEGPPFASIQELIMHQYHSELPVTVKSGAI 1046
                      ||     |.|:.:            :|.|..|      :|::..||..|      
Human   572 SKHGADEKRLHF-----GNGHLKLPGLRTYVDPHTYEDPTQA------VHEFAKELDAT------ 619

  Fly  1047 LRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLK---STKLDVAVKTCRMTLPDEQKRKFLQ 1108
                      .:|.|.||     |.|.||:|...:||   ..::.||:||.::...::|:|.||.
Human   620 ----------NISIDKVV-----GAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLG 669

  Fly  1109 EGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGM 1173
            |..|:.|:|||||::|.|:..:.:|:|||.|.:..|||.::|||:....|..|.:||.|..|:||
Human   670 EASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGM 734

  Fly  1174 RYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-----EEEEYIVSDGMKQIPVKWTAPEALN 1233
            :||.....:||||||||.|::.....|:||||:||     .|..|....|  :||::||:|||:.
Human   735 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG--KIPIRWTSPEAIA 797

  Fly  1234 FGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWA 1298
            :.|:||..|||||||::||:.|.|:.||..|:|....:.:|.|||:|.|...|..:|:|||.||.
Human   798 YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQ 862

  Fly  1299 ADAESRPHFDEIYNVVDALI 1318
            .|..:||.|::|.:::|.||
Human   863 KDRNNRPKFEQIVSILDKLI 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 21/128 (16%)
TyrKc 1063..1311 CDD:197581 109/255 (43%)
PTKc_Fes_like 1067..1315 CDD:270637 108/255 (42%)
EPHA3NP_005224.2 EphR_LBD_A3 29..201 CDD:198449
fn3 327..417 CDD:278470 18/104 (17%)
FN3 437..528 CDD:238020 18/112 (16%)
EphA2_TM 555..616 CDD:291255 11/73 (15%)
PTKc_EphR_A 616..882 CDD:270651 115/288 (40%)
Pkinase_Tyr 621..878 CDD:285015 112/263 (43%)
SAM 908..975 CDD:197735
SAM_superfamily 912..974 CDD:301707
PDZ-binding. /evidence=ECO:0000255 981..983
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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