DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and EPHA1

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_005223.4 Gene:EPHA1 / 2041 HGNCID:3385 Length:976 Species:Homo sapiens


Alignment Length:714 Identity:178/714 - (24%)
Similarity:283/714 - (39%) Gaps:190/714 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   721 LVRMGKNHILNEEQDAKRTQPSQHHHSSGS---DCPTNS--------------SSSSSNNNNNNK 768
            ||.:|:.|          .:|......||.   .||:.|              ..|::.:.....
Human   256 LVPVGRCH----------CEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATI 310

  Fly   769 NTSSNSNHSA-SQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNF 832
            .|..:.::.| .:...:..|...:.....:.:.|.....|:::.|......:.:|.:.|      
Human   311 CTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVR------ 369

  Fly   833 QLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCN-C------PPAGQKPVKPS 890
                   |.||                        .|:|.|...|. |      .|..:....|:
Human   370 -------CSQC------------------------QGTAQDGGPCQPCGVGVHFSPGARGLTTPA 403

  Fly   891 VQISGHKDHPFESSSGELD-ENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRP 954
            |.::|.:  |:.:.:..:: :|....:.:......|.|   :|| .|...:..|  |:.|....|
Human   404 VHVNGLE--PYANYTFNVEAQNGVSGLGSSGHASTSVS---ISM-GHAESLSGL--SLRLVKKEP 460

  Fly   955 LYEEEWFHGVLPREEVVRL------LNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEG 1013
            ...|..:.|..||.....|      ||.|          .|..|:||.     .:..:.:...:.
Human   461 RQLELTWAGSRPRSPGANLTYELHVLNQD----------EERYQMVLE-----PRVLLTELQPDT 510

  Fly  1014 NFRFE-------GP-PFASIQELIMHQYHSELPVT--------------VKSGAIL--------R 1048
            .:...       || ||:.     .|::.:..||:              :..||.|        .
Human   511 TYIVRVRMLTPLGPGPFSP-----DHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRS 570

  Fly  1049 RPVCRERWELSNDDVVLLER---------------------------------------IGRGNF 1074
            |...|:|.:...|....::|                                       ||.|.|
Human   571 RRAQRQRQQRQRDRATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEF 635

  Fly  1075 GDVYKAKLKSTKLD---VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMI 1136
            |:||:..|:....|   ||:||.:.|.|..|...||:|..|:.|:.||:|:.|.|:..:::||||
Human   636 GEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMI 700

  Fly  1137 VMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKI 1201
            :.|.:..|:|..:||:..:.|...|.:.|.:..|:||.||.:.|.:||||||||.||:.....|:
Human   701 ITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKV 765

  Fly  1202 SDFGMSREEEEYIVSDGMKQ-----IPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPY 1261
            ||||::|..:::   ||..:     ||::||||||:....:|:..||||:||:|||:.|.||.||
Human   766 SDFGLTRLLDDF---DGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPY 827

  Fly  1262 SGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNSH 1325
            ..|:|....:.|:.|||:|.|...|..:|.||..|||.|...||||.::...::.|   |.|.|
Human   828 GEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQL---LANPH 888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 18/99 (18%)
TyrKc 1063..1311 CDD:197581 106/294 (36%)
PTKc_Fes_like 1067..1315 CDD:270637 106/294 (36%)
EPHA1NP_005223.4 EphR_LBD_A1 27..203 CDD:198447
fn3 334..431 CDD:278470 19/135 (14%)
FN3 453..535 CDD:238020 19/101 (19%)
PKc_like 619..884 CDD:304357 106/270 (39%)
Pkinase_Tyr 624..880 CDD:285015 105/258 (41%)
SAM 911..976 CDD:197735
SAM_EPH-A1 912..974 CDD:188941
PDZ-binding. /evidence=ECO:0000255 974..976
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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