DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Ros1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_011241449.1	Gene:	Ros1 / 19886	MGIID:	97999	Length:	2341	Species:	Mus musculus

Alignment Length:	808	Identity:	203/808 - (25%)
Similarity:	324/808 - (40%)	Gaps:	215/808 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   632 ELNRV-LDDRLKRTLQPSDDVNAIES-----------AEENH----IQTRKLAKDPDSQTKRSSS 680
            |.||. ..||..:.|:..::|..||.           |.:|:    ::...|.|:...||| |..
Mouse  1488 EANRANSSDRRHKMLESQENVARIEGLQPFSMYMIQIAVKNYYSEPLEHLPLGKEIQGQTK-SGV 1551

  Fly   681 SSSECRSS----KDTS-----------HSKKRSLSFSQKSISNIFSNLKEFSKSPL--------- 721
            ..:.|..:    .|||           :..|.|:.:..     :.|.|....::||
Mouse  1552 PGAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQL-----VMSYLAPIPETPLRQGEFPSAK 1611

  Fly   722 -------VRMGKNHILN------EEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSN 773
                   :..|:.:::.      ||.....:.|..   .:..|.|...|:....|.:...:..:.
Mouse  1612 LSLLITKLSGGQLYVMKVLACHPEEMWCTESHPVS---VNMFDTPEKPSALVPENTSLQLDWKAR 1673

  Fly   774 SN-------------------H---SASQSTIITSTIT-------------TTITTTTTTTPSKE 803
            ||                   |   |.||..:....||             ...||...::...|
Mouse  1674 SNVNLTGFWFELQKWKYNEFYHVKASCSQGPVYVCNITDLQPYTSYNIRVVVVYTTGENSSSIPE 1738

  Fly   804 NSRLKFKVPK---IQKKSKAIRNTFR--------SKLLNFQLKRSKPCKQCTKRRRIHPSKSVFD 857
            :.:.|..||.   |.|..:..:|:.:        |:|:.:.|:..|.....::.:... .|.||:
Mouse  1739 SFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKGISNDSQNQSSR-WKVVFN 1802

  Fly   858 FAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEE 922
                       ||.:  ..|..   ..|.:|.:.|......:  |...||..|
Mouse  1803 -----------GSCS--SICTW---RSKNLKGTFQFRAVAAN--EIGLGEYSE------------ 1837

  Fly   923 EDSASDDVLSMKDHCYC-----VPSLAASISLSTNRPLYEEEWFHGVLPR---EEVVRLLNNDGD 979
               .|:|:..::|..:.     :.::...|.|....|| ...|...:...   :|.:.:| ||.|
Mouse  1838 ---ISEDITLVEDGVWITETSFILTIIVGIFLVATVPL-TFVWHRSLKSHKASKEGLSVL-NDND 1897

  Fly   980 FLVRETIRNEESQIVL-SVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKS 1043
            ..:.| :|...:.:.| :.|:..|   .|.|                ||.|     ..||...:.
Mouse  1898 KELAE-LRGLAAGVGLANACYAVH---TVPT----------------QEEI-----ENLPAFPRE 1937

  Fly  1044 GAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAK------LKSTKLDVAVKTCRMTLPDEQ 1102
            ...||                ||  :|.|.||:||:..      :.|.::.|||||.:....|::
Mouse  1938 KLSLR----------------LL--LGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQE 1984

  Fly  1103 KRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK------NSNGLTTRQ 1161
            |.:||:|..::.:::||||:|.:|:|:..:|..|::||:.||.||:||||      :...||...
Mouse  1985 KIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGPSLTLLD 2049

  Fly  1162 QMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLE-----HSVKISDFGMSRE--EEEYIVSDGM 1219
            .:.:|.|.:.|..|||..:.||||||||||||.::     ..|||.|||::||  :.:|....|.
Mouse  2050 LVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGE 2114

  Fly  1220 KQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKS 1284
            ..:||:|.|||.|..|.:||..||||:|||:|||.:.|..||...:|......:..|.|:..|::
Mouse  2115 GLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRN 2179

  Fly  1285 TPEEMYRLMLQCWAADAESRPHFDEIYN 1312
            .|::::.||.||||.:.:.||.|..|.|
Mouse  2180 CPDDLWNLMSQCWAQEPDQRPTFHNIQN 2207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	19/89 (21%)
		TyrKc	1063..1311	CDD:197581	105/266 (39%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/265 (40%)
Ros1	XP_011241449.1	FN3	112..179	CDD:214495
		FN3	207..291	CDD:238020
		FN3	568..664	CDD:238020
		FN3	1037..1143	CDD:238020
		FN3	1552..1631	CDD:238020	11/83 (13%)
		FN3	1651..1742	CDD:238020	15/90 (17%)
		FN3	1747..1840	CDD:238020	21/126 (17%)
		PTKc_c-ros	1949..2210	CDD:270640	103/259 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910