DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Ripk1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001346926.1	Gene:	Ripk1 / 19766	MGIID:	108212	Length:	656	Species:	Mus musculus

Alignment Length:	287	Identity:	87/287 - (30%)
Similarity:	138/287 - (48%)	Gaps:	47/287 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 ELSNDDVV-----LLER--IGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPD--EQKRKFLQEGRI 1112
            ::|.|::.     |||:  :..|.||.|.....:|....:..|.  .|.|:  |.....|:||::
Mouse     4 DMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKV--YTGPNRAEYNEVLLEEGKM 66

  Fly  1113 LKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN---GLTTRQQMGMCRDAAAGMR 1174
            :.:..|..:|||:||.:::....:|||.:..|:|:..|:...:   .|..|    :..:|..||.
Mouse    67 MHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGR----IIVEAIEGMC 127

  Fly  1175 YLESKNCIHRDLAARNCLVDLEHSVKISDFGMS-----------REEEEYIVSDGMKQI---PVK 1225
            ||..|..||:||...|.|||.:..:||:|.|::           ::.::..||...|:.   .:.
Mouse   128 YLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLY 192

  Fly  1226 WTAPEALN--FGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARER----IDTGYRMPTPKS 1284
            :.|||.||  ..|.|...||:|:||::|.||:|.: ||.   |....|:    |.:|.| |..:.
Mouse   193 YMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKE-PYE---NVICTEQFVICIKSGNR-PNVEE 252

  Fly  1285 ----TPEEMYRLMLQCWAADAESRPHF 1307
                .|.|:..||.:||.|..|.||.|
Mouse   253 ILEYCPREIISLMERCWQAIPEDRPTF 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	85/281 (30%)
		PTKc_Fes_like	1067..1315	CDD:270637	83/272 (31%)
Ripk1	NP_001346926.1	PKc_like	23..291	CDD:419665	82/268 (31%)
		Interaction with SQSTM1. /evidence=ECO:0000250\|UniProtKB:Q13546	291..567
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..373
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..423
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:18442983, ECO:0000269\|PubMed:27819681, ECO:0000269\|PubMed:27819682	520..536
		Death_RIP1	568..653	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900