DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and EPHA2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_004422.2	Gene:	EPHA2 / 1969	HGNCID:	3386	Length:	976	Species:	Homo sapiens

Alignment Length:	293	Identity:	115/293 - (39%)
Similarity:	177/293 - (60%)	Gaps:	26/293 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1045 AILR-----RPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKST----KLDVAVKTCRMTLPD 1100
            |:|:     .|.|..|.::          ||.|.||:|||..||::    ::.||:||.:....:
Human   600 AVLKFTTEIHPSCVTRQKV----------IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTE 654

  Fly  1101 EQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGM 1165
            :|:..||.|..|:.|:.|.||::|.|:..:.:|:||:.|.:..|:|..:||:.....:..|.:||
Human   655 KQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGM 719

  Fly  1166 CRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-----EEEEYIVSDGMKQIPVK 1225
            .|..||||:||.:.|.:||||||||.||:.....|:||||:||     .|..|..|.|  :||::
Human   720 LRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGG--KIPIR 782

  Fly  1226 WTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMY 1290
            ||||||:::.|:||..||||:||:|||:.:.|:.||..::|....:.|:.|:|:|||...|..:|
Human   783 WTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIY 847

  Fly  1291 RLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            :||:|||..:...||.|.:|.:::|.||...|:
Human   848 QLMMQCWQQERARRPKFADIVSILDKLIRAPDS 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	105/256 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	106/256 (41%)
EPHA2	NP_004422.2	EphR_LBD_A2	28..201	CDD:198448
		fn3	330..418	CDD:365830
		fn3	438..516	CDD:365830
		EphA2_TM	<556..608	CDD:373140	2/7 (29%)
		PTKc_EphR_A2	607..875	CDD:133194	110/279 (39%)
		SAM_EPH-A2	902..971	CDD:188942
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910