DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and EGFR

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_005219.2	Gene:	EGFR / 1956	HGNCID:	3236	Length:	1210	Species:	Homo sapiens

Alignment Length:	1240	Identity:	254/1240 - (20%)
Similarity:	429/1240 - (34%)	Gaps:	433/1240 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 THNEYVLSITEAIEVEKDFRN--VLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEI 248
            |..::.||:      ::.|.|  |:| |.||... ||.::.|.:...:||.|.|..:..:..:.|
Human    43 TFEDHFLSL------QRMFNNCEVVL-GNLEITY-VQRNYDLSFLKTIQEVAGYVLIALNTVERI 99

  Fly   249 Q-KRIDTVIGSINPTEEYGEFTEKYKTSPTTPLLFQFD--ETLIQDIPGKLQSSTLTVDNLTVDW 310
            . :.:..:.|::           .|:.|....:|..:|  :|.::::|
Human   100 PLENLQIIRGNM-----------YYENSYALAVLSNYDANKTGLKELP----------------- 136

  Fly   311 LRNRLQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNAL 375
            :||..:.|.||||......:..:|.:.....|::..:    ||.|...|::..| |:
Human   137 MRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFL----SNMSMDFQNHLGS-CQ-------- 188

  Fly   376 RCQ------------EKQKQKLVDMIKCALNEVG-CE-ELPSGCDDDLTLEQNFIENGYNNEQQR 426
            :|.            |:..|||..:| ||....| |. :.||.|                ...|.
Human   189 KCDPSCPNGSCWGAGEENCQKLTKII-CAQQCSGRCRGKSPSDC----------------CHNQC 236

  Fly   427 SNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATP-----------MTRSRQGRFNK 480
            :...:.|         |....|..     |.|:.::|.:...|           |..:.:|::
Human   237 AAGCTGP---------RESDCLVC-----RKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKY-- 285

  Fly   481 LQPRSQSLGSLSVIRDGNGPSPARYEPITNHR--LRQAASVHYLGEEIATSSTNPPDLTRLRRTQ 543
                  |.|:..|.:     .|..| .:|:|.  :|...:..|..||        ..:.:.::.:
Human   286 ------SFGATCVKK-----CPRNY-VVTDHGSCVRACGADSYEMEE--------DGVRKCKKCE 330

  Fly   544 --CSMLC----LGEDEEPVVLASPAPLTQLTAAVLTNTNNNH------IYADLEL-------DKK 589
              |..:|    :||.::.:.:.:              ||..|      |..||.:       |..
Human   331 GPCRKVCNGIGIGEFKDSLSINA--------------TNIKHFKNCTSISGDLHILPVAFRGDSF 381

  Fly   590 KDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAI 654
            ..|.|....:.:.::..||.....:.|..|:|..|.|                          |.
Human   382 THTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLH--------------------------AF 420

  Fly   655 ESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSIS-NIFS----NLK 714
            |:.|....:|::                          |.:     ||...:| ||.|    :||
Human   421 ENLEIIRGRTKQ--------------------------HGQ-----FSLAVVSLNITSLGLRSLK 454

  Fly   715 EFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSAS 779
            |.|...::..|..::                      |..|:.:.......:.:.|...||..
Human   455 EISDGDVIISGNKNL----------------------CYANTINWKKLFGTSGQKTKIISNRG-- 495

  Fly   780 QSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCT 844
                                   |||                                  ||
Human   496 -----------------------ENS----------------------------------CK--- 500

  Fly   845 KRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCN--CPPAGQKPVKPSVQISGH----------K 897
                                       |..|.|:  |.|.|....:|...:|..          |
Human   501 ---------------------------ATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDK 538

  Fly   898 DHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFH 962
            .:..|....|..|||:                  .::.|..|:|. |.:|:.:...|....:..|
Human   539 CNLLEGEPREFVENSE------------------CIQCHPECLPQ-AMNITCTGRGPDNCIQCAH 584

  Fly   963 GVLPREEVVRLLNNDGDFLVRET---IRNEESQIVLS------VCWNGHKHFIVQTTGEG--NFR 1016
            .:            ||...|:..   :..|.:.:|..      ||...|.:.....||.|  ...
Human   585 YI------------DGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCP 637

  Fly  1017 FEGPPFASIQELIMHQYHSELPVTVKSGAIL-RRPVCRER------------------WELSNDD 1062
            ..||...||...::......|.|.:..|..: ||.:.|:|                  .|..|..
Human   638 TNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQA 702

  Fly  1063 VVLLER---------IGRGNFGDVYKA----KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILK 1114
            ::.:.:         :|.|.||.|||.    :.:..|:.||:|..|.....:..::.|.|..::.
Human   703 LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 767

  Fly  1115 QYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESK 1179
            ..|:|::.:|:|||: ...:.::.:|:..|.||.|:|::.:.:.::..:..|...|.||.|||.:
Human   768 SVDNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR 831

  Fly  1180 NCIHRDLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSL 1240
            ..:||||||||.||.....|||:|||:::    ||:||....|  ::|:||.|.|::....||..
Human   832 RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGG--KVPIKWMALESILHRIYTHQ 894

  Fly  1241 CDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRP 1305
            .||||||:.:||:.:.|..||.|:..|.....::.|.|:|.|.....::|.:|::||..||:|||
Human   895 SDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRP 959

  Fly  1306 HFDEI 1310
            .|.|:
Human   960 KFREL 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	17/58 (29%)
		SH2_Fps_family	953..1039	CDD:198224	18/96 (19%)
		TyrKc	1063..1311	CDD:197581	89/265 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	89/261 (34%)
EGFR	NP_005219.2	Recep_L_domain	57..168	CDD:279382	29/140 (21%)
		Approximate	75..300		56/310 (18%)
		Furin-like	185..335	CDD:279142	37/211 (18%)
		FU	231..274	CDD:238021	9/72 (13%)
		Recep_L_domain	361..481	CDD:279382	31/198 (16%)
		Approximate	390..600		57/408 (14%)
		GF_recep_IV	505..637	CDD:291509	30/162 (19%)
		FU	506..559	CDD:238021	12/70 (17%)
		FU	552..598	CDD:214589	12/76 (16%)
		TM_ErbB1	634..677	CDD:213054	10/42 (24%)
		Important for dimerization, phosphorylation and activation	688..704		2/15 (13%)
		PTKc_EGFR	704..1016	CDD:270683	89/264 (34%)
		TyrKc	713..968	CDD:197581	89/255 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1137
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910