DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Fnbp1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_620269.1	Gene:	Fnbp1 / 192348	RGDID:	621350	Length:	620	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	130/725 - (17%)
Similarity:	245/725 - (33%)	Gaps:	273/725 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LDHQAKQFKFNAEQLEV---VCDKLTHLSQDKRKARKAYQEEHAKIAA------RLNHLTD---- 131
            :|...|..||..|:.|:   ...:|.:||:..:..:.:.:||..|..|      .||.|.|
  Rat    22 IDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTACKAFLSTLNELNDYAGQ 86

  Fly   132 -EVVRKKSEYQKHLEGYKALRTRFEENYIKAPSRSGRK-----------LDDVRDKYQKACRKLH 184
             ||:.:....|..::..:.::...:|.  |:....|||           |:..:.::::.|::..
  Rat    87 HEVISENMTSQITVDLVRYVQELKQER--KSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEAD 149

  Fly   185 LTHNEYV-----LSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADK 244
            .....:.     :::|:| :|||           ..||:          .:.|:.|:  |..||
  Rat   150 RAQQYFEKMDADINVTKA-DVEK-----------ARQQA----------QMRQQMAE--DSKAD- 189

  Fly   245 YKEIQKRIDTVIGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVD 309
            |..|.:|.:         :|..|:   |.|.  .|.:||           |:|           :
  Rat   190 YSLILQRFN---------QEQWEY---YHTH--IPNIFQ-----------KIQ-----------E 218

  Fly   310 WLRNRLQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNA 374
            ....|:..:..:::...|...::|       |:....:               |.:.:.::.::
  Rat   219 MEERRIVRIGESMKTYAEVDRQVI-------PIIGKCL---------------DGIVKAAESID- 260

  Fly   375 LRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRS---NSTSS---- 432
               |:...|.:|:..|......|          |:..|.      |....:|:   ||.||
  Rat   261 ---QKNDSQLVVEAYKSGFEPPG----------DIEFED------YTQPMKRTVSDNSLSSSKEG 306

  Fly   433 -PGL-------GIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLG 489
             |.|       |.:...:::..::|||         .|..||..|            .|.|.|..
  Rat   307 KPELKFGGKSRGKLWPFIKKNKLMTLL---------TSPHQPPPP------------PPASASPS 350

  Fly   490 SLSVIRDGNGP-SPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDE 553
            ::.     ||| ||.:.:...:||..:
  Rat   351 AVP-----NGPQSPKQQKEPLSHRFNE-------------------------------------- 372

  Fly   554 EPVVLASPAPLTQLTAAVLTNTNNNHIYADLE--LDKKKDTSPS------PECKGEQIQPKKEQI 610
                             .:|:....|.:..|:  |..|...:|.      ||.:.:::|.|.:.:
  Rat   373 -----------------FMTSKPKIHCFRSLKRGLSLKLGVTPEDFSNFPPEQRRKKLQQKVDDL 420

  Fly   611 RIEINQTAPQNSIDAHLDRIDELNRV------------LDDRLKRTLQPSD----DVNAIES--A 657
            ..||.:...|.      |.|.::..|            ||.:|....|..:    :.:..|:  |
  Rat   421 NKEIQKETDQR------DAITKMKDVYLKNPQMGDPASLDHKLAEVTQNIEKLRLEAHKFEAWLA 479

  Fly   658 E-ENHI-----QTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEF 716
            | |..:     |.|:.:...|.||.::.::.::.|.|.|.|:::::|.....|.::..|.:  ||
  Rat   480 EVEGRLPARSEQARRQSGLYDGQTHQTVTNCAQDRESPDGSYTEEQSQESEHKVLATDFDD--EF 542

  Fly   717 -SKSPLVRMG 725
             .:.||..:|
  Rat   543 DDEEPLPAIG 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	37/192 (19%)
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
Fnbp1	NP_620269.1	Interaction with microtubules	1..334		75/425 (18%)
		Required for self-association and induction of membrane tubulation. /evidence=ECO:0000250	1..79		14/56 (25%)
		F-BAR_FBP17	5..257	CDD:153360	56/319 (18%)
		Required for self-association and induction of membrane tubulation. /evidence=ECO:0000250	251..616		74/411 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..314		11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..365		14/58 (24%)
		Interaction with RND2	399..551		34/159 (21%)
		HR1_FBP17	406..482	CDD:212019	17/81 (21%)
		Interaction with PDE6G	494..616		15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..531		8/36 (22%)
		Required for interaction with TNKS. /evidence=ECO:0000250	513..616		12/42 (29%)
		Interaction with DNM1 and DNM3. /evidence=ECO:0000250	534..616		6/21 (29%)
		Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000250	549..616		1/4 (25%)
		Interaction with FASLG. /evidence=ECO:0000250	552..609		1/1 (100%)
		Interaction with DNM2 and WASL. /evidence=ECO:0000250	552..608		1/1 (100%)
		SH3_FBP17	552..608	CDD:213004	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910