DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Ptk2b

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_017171415.1	Gene:	Ptk2b / 19229	MGIID:	104908	Length:	1020	Species:	Mus musculus

Alignment Length:	373	Identity:	125/373 - (33%)
Similarity:	187/373 - (50%)	Gaps:	62/373 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   989 EESQIVLSVCWNGHKHFI-VQTTG-----------EGNFRFEGPPFASIQELIMH---------- 1031
            ||:|.||.:...|....: ::|:.           :|..|.:|....|   ||||
Mouse   314 EETQAVLQLGIEGAPQSLSIKTSSLAEAENMADLIDGYCRLQGEHKGS---LIMHAKKDGEKRNS 375

  Fly  1032 ------------------------QYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRG 1072
                                    ..::|:|     ...|||| ...::.::.::|||...:|.|
Mouse   376 LPQIPTLNLEARRSHLSESCSIESDIYAEIP-----DETLRRP-GGPQYGVAREEVVLNRILGEG 434

  Fly  1073 NFGDVYK---AKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPI 1134
            .||:||:   ...|..|::||||||:.....:.|.||:.|..|:|..|||:||||||| ::::|.
Mouse   435 FFGEVYEGVYTNHKGEKINVAVKTCKKDCTQDNKEKFMSEAVIMKNLDHPHIVKLIGI-IEEEPT 498

  Fly  1135 MIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSV 1199
            .|:|||...|.|..||.:|.|.|.....:.........|.||||.||:|||:|.||.||.....|
Mouse   499 WIIMELYPYGELGHYLERNKNSLKVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECV 563

  Fly  1200 KISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYS 1262
            |:.|||:||  |:|:|..: .:.::|:||.:||::||.::|:..|||.:.:.||||.|.|..|:.
Mouse   564 KLGDFGLSRYIEDEDYYKA-SVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFF 627

  Fly  1263 GMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            .:.|......::.|.|:|.|:..|..:|.||.:||..|...||.|.|:
Mouse   628 WLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTEL 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	16/95 (17%)
		TyrKc	1063..1311	CDD:197581	104/253 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/249 (41%)
Ptk2b	XP_017171415.1	FERM_N_2	39..137	CDD:407875
		B41	41..254	CDD:214604
		FERM_C_FAK1	261..368	CDD:270011	15/56 (27%)
		PTKc_FAK	418..687	CDD:133187	104/260 (40%)
		Focal_AT	883..1012	CDD:397606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910