DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and gcy-19

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001348702.1	Gene:	gcy-19 / 191650	WormBaseID:	WBGene00001544	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	240	Identity:	54/240 - (22%)
Similarity:	100/240 - (41%)	Gaps:	47/240 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1113 LKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLE 1177
            |::.||.|:.|.:|:.:.....:.|.:|.:.|||...:.:.:..:.......:.||.|.|::||.
Worm   626 LRKLDHENVNKFVGMSIDGPEYLAVWKLCMRGSLQDIIGQGNFSIDPFFMFCVIRDMAEGLKYLH 690

  Fly  1178 SKNC-IHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVK----WTAPEALNFGKY 1237
            :... :|.:|.:...||:.....|::|||:....||        :.|:|    |.|||.:   :.
Worm   691 NSFLHVHANLRSGTVLVNESWQAKLTDFGLGTLAEE--------KKPMKRRQLWMAPEVI---RG 744

  Fly  1238 TSL-------CDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDT-----------GYRMPTPK- 1283
            |.|       .|::|..::..|:.::.:.       ....||.||           |...|.|:
Worm   745 TLLPHQIEKSADIYSLAVIASEVLTRKEA-------WNMAERKDTVDEIVYRIKKGGPNAPRPEL 802

  Fly  1284 -----STPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
                 .....:..|:..||:.:...||..|.|.|::..::.:..|
Worm   803 DMDGVEINHNLLILIRDCWSEEPADRPSADVICNLLKNMMPKKGN 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	51/226 (23%)
		PTKc_Fes_like	1067..1315	CDD:270637	53/230 (23%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347
		PKc_like	571..841	CDD:328722	53/232 (23%)
		CYCc	876..1065	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900