DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and gcy-14

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_506660.2	Gene:	gcy-14 / 191647	WormBaseID:	WBGene00001540	Length:	1111	Species:	Caenorhabditis elegans

Alignment Length:	331	Identity:	74/331 - (22%)
Similarity:	126/331 - (38%)	Gaps:	91/331 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1021 PFASIQ--------ELIMHQYHS----ELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGN 1073
            ||..:|        |..||.:.|    ...:||:|.:                     |.|   |
Worm   516 PFIELQQVQSKSKAEASMHSFASGPSTSTKITVESRS---------------------ETI---N 556

  Fly  1074 FGDVYKAK--LKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMI 1136
            |...|..:  |.:.|.|:.::     ...|||.:|.|    ::.:|:.|:.|.||:|:....:..
Worm   557 FIFYYYQQDILAAMKHDLILQ-----FDAEQKAEFRQ----MRNFDNDNLNKFIGLCLDGPQLFS 612

  Fly  1137 VMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESK--NCIHRDLAARNCLVDLEHSV 1199
            :......|||...:.|:|..:.:.....:.||.:.|:.::.:.  .| |..|.:|.||:|....:
Worm   613 LWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISNGLLFIHNSFLKC-HGHLTSRCCLIDDRWQI 676

  Fly  1200 KISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSL--CDVWSYGILMWEIFSK------ 1256
            |||.:|:    :.....:..|:..:.||.||.|.......|  .|::|:||:..||.::
Worm   677 KISGYGL----KSVRTFENPKKEDLLWTPPENLRNENEERLPEGDIYSFGIICSEILTRSSAFDL 737

  Fly  1257 -----------------GDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESR 1304
                             |..|        .|..:|||   .|.:..| .:..|:..||......|
Worm   738 ENRKEKPDVIIYQVKKGGHNP--------MRPSLDTG---ETVEINP-ALLHLIRDCWTERPSER 790

  Fly  1305 PHFDEI 1310
            |..:::
Worm   791 PSIEQV 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	7/29 (24%)
		TyrKc	1063..1311	CDD:197581	64/277 (23%)
		PTKc_Fes_like	1067..1315	CDD:270637	64/273 (23%)
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347
		ANF_receptor	43..418	CDD:279440
		PKc_like	535..800	CDD:304357	68/312 (22%)
		HNOBA	<817..860	CDD:285003
		CYCc	839..1031	CDD:214485
		Guanylate_cyc	866..1053	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900