DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and gcy-13

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_506097.3	Gene:	gcy-13 / 191646	WormBaseID:	WBGene00001539	Length:	1028	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	81/358 - (22%)
Similarity:	136/358 - (37%)	Gaps:	79/358 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   980 FLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELI---MHQYHSELPV-- 1039
            |||.:..|:||.::        ...:||             |...:|.:|   ...:||...:
Worm   458 FLVIKARRDEELRL--------DDQWIV-------------PHGMLQSIIKGRKESHHSSRSLQS 501

  Fly  1040 --TVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLP-DE 1101
              |..:|..          .:|:..|...|...:|.|  ||..:      .|..:..::.:| .:
Worm   502 NSTTTTGTT----------GISSRSVFFPETETQGYF--VYMNE------PVLARKYQLRVPIFK 548

  Fly  1102 QKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMC 1166
            |.|   .|.|:|:..:|.|:.:.||:.:.....|........||:...:.|:|..:.......:.
Worm   549 QDR---SELRMLRSIEHDNVNRFIGLSIDGPVYMSFWRYCSRGSIKDVIAKSSINMDGFFIYCLI 610

  Fly  1167 RDAAAGMRYL-ESKNCIHRDLAARNCLVDLEHSVKISDFGMS-REEEEYIVSDGMKQIPVKWTAP 1229
            :|.|:|::|: .|....|..|.:..|.::....|||..:|:| .:..|....||:..     |||
Worm   611 KDIASGLQYIHHSPIKQHGSLTSECCYINDRWQVKIGSYGLSFMQGVEKRTEDGLLH-----TAP 670

  Fly  1230 EALNFG--KYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARER--------IDTGYRMPTPKS 1284
            |.|..|  ..|...||:|:.|:..|:..     :|...|...|:.        :..|.|.|...|
Worm   671 EVLREGLTSGTQAGDVYSFSIVCSELVG-----HSSAWNLENRKEEADEIIFMVKRGGRTPFRPS 730

  Fly  1285 TPE-------EMYRLMLQCWAADAESRPHFDEI 1310
            ..:       .|..|:..||..|.:.||:.|.:
Worm   731 LDDVDDDINPAMLHLIRDCWDEDPKQRPNIDMV 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	13/61 (21%)
		TyrKc	1063..1311	CDD:197581	65/268 (24%)
		PTKc_Fes_like	1067..1315	CDD:270637	64/264 (24%)
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347
		ANF_receptor	13..368	CDD:279440
		PKc_like	548..770	CDD:304357	57/229 (25%)
		HNOBA	<797..829	CDD:285003
		CYCc	808..1000	CDD:214485
		Guanylate_cyc	835..1022	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900