DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and gcy-6

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001294696.1	Gene:	gcy-6 / 191644	WormBaseID:	WBGene00001533	Length:	1086	Species:	Caenorhabditis elegans

Alignment Length:	305	Identity:	70/305 - (22%)
Similarity:	120/305 - (39%)	Gaps:	69/305 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1056 WELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPN 1120
            :::.||  |.:||:.         ||..|.::....|||...             |.::..||.|
Worm   575 FQIQND--VEMERVA---------AKKHSIRMVFDNKTCATM-------------RQMRLIDHAN 615

  Fly  1121 IVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYL-ESKNCIHR 1184
            :.|.||:.:....:..|......|||...:||.|..:.......:.:|...|:.:: ||.:..|.
Worm   616 LNKFIGMSLDAPQLYSVWRFCSRGSLADVIRKASMQMDGFFIYSLMKDIINGLTWIHESSHEFHG 680

  Fly  1185 DLAARNCLVDLEHSVKISDFGMS--REEEEYIVSDGMKQIPVKWTAPEALN----FGKYTSLCDV 1243
            .|.::|||::....:||:|||:.  |..::|..||.:      ||:||.|.    .|....  |:
Worm   681 MLTSKNCLLNDRWQLKITDFGLRIFRTHDQYNKSDRL------WTSPELLRTDDILGSREG--DI 737

  Fly  1244 WSYGILMWEIFSKGDTPYSGMTNSRARERI----DTGYRMPTPKSTPEE-------MYRLMLQCW 1297
            :|:||:..|:.::............|.|.|    ..|.:.|.|....:|       :..|:..||
Worm   738 YSFGIISAELITRSSVFDLENRKEDAEEIIYMLKKGGLQSPRPSLEHDESIEINPALLHLVRDCW 802

  Fly  1298 AADAESRPH-------------------FDEIYNVVDALILRLDN 1323
            ......||.                   .|.::||:::....|::
Worm   803 TERPSERPDIKQVASQLRSMNTNRNDNLMDHVFNVLESYASTLED 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	65/284 (23%)
		PTKc_Fes_like	1067..1315	CDD:270637	66/284 (23%)
gcy-6	NP_001294696.1	PBP1_NPR_GC_like	29..445	CDD:107347
		ANF_receptor	57..424	CDD:279440
		PKc_like	585..822	CDD:304357	62/266 (23%)
		HNOBA	<847..879	CDD:285003	0/1 (0%)
		CYCc	858..1048	CDD:214485
		Guanylate_cyc	885..1070	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900