DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and gcy-3

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_496037.1	Gene:	gcy-3 / 191641	WormBaseID:	WBGene00001530	Length:	1140	Species:	Caenorhabditis elegans

Alignment Length:	472	Identity:	107/472 - (22%)
Similarity:	172/472 - (36%)	Gaps:	126/472 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   924 DSASDDVLSMKDHCYCVPSLAAS-------ISLSTN---RPLYEEEWFHGVLPREEVVRLLN--- 975
            |||..|.:|.     .:|....|       ::::.|   .|||:   .:|:..:.|...|:|
Worm   388 DSAVYDDMSK-----LIPQFVTSFNGMTGLVAINQNLSRMPLYQ---LYGLDEQYEQTSLMNLSF 444

  Fly   976 NDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGP----PFASIQELIMHQYHSE 1036
            .||..:...::........:...|.|.:.......|     |.|.    ||       ..||  .
Worm   445 ADGTTVATISLAYSNESSAVWHFWGGIRPLATPICG-----FLGNSCPLPF-------WEQY--G 495

  Fly  1037 LPVTVKSGAIL----RRPVC--------RE-------RWELSNDDVVLLERIGRG---------- 1072
            :.:.|.:|..|    ...:|        ||       .|::....:..|||..:|
Worm   496 ILIFVGAGVFLIMITTNLICFLFMIKNRREEQARINSEWQIPFVKLRELERKSKGTSKRSLQSAP 560

  Fly  1073 -------------NFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKL 1124
                         .|.:.|:.|:....:.:.:|...|.|......||::    |::.||.|:.|.
Worm   561 STITGESKVSTGSEFCENYEVKMFEKDMVLTMKFQYMNLNKADMDKFVK----LRKLDHENLNKF 621

  Fly  1125 IGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYL-ESKNCIHRDLAA 1188
            ||:.:.....:.|.:|...||||..|.|.:..:.......:.:|.|.||.|| :|...:|.:|.:
Worm   622 IGLSIDSSQFISVTKLCSRGSLLDILYKGNFSMDFFFMYCIIKDVAEGMSYLHKSFLRLHGNLRS 686

  Fly  1189 RNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVK----WTAPEALNFGKYT-----SLCDVW 1244
            ..|||:....||:::||..:..||.        .|.|    |.|||.|. |..|     ...||:
Worm   687 ATCLVNDSWQVKLAEFGFDQLLEEI--------TPTKRRLLWAAPEVLR-GSLTVSQMDPSADVF 742

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARE--------RIDTGYRMP--------TPKSTPEEMYRLM 1293
            |:.|:..||.::.:.     .:.:.|:        |:..|...|        .|...| .:..|:
Worm   743 SFAIIASEILTRKEA-----WDLKERKEGYDEIIYRVKKGGSFPIRPDIITDVPDVNP-TLIALV 801

  Fly  1294 LQCWAADAESRPHFDEI 1310
            ..|||...|.||..:.|
Worm   802 KDCWAEAPEDRPTAENI 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/92 (20%)
		TyrKc	1063..1311	CDD:197581	74/297 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	73/293 (25%)
gcy-3	NP_496037.1	PBP1_NPR_GC_like	36..453	CDD:107347	17/72 (24%)
		ANF_receptor	54..433	CDD:279440	12/52 (23%)
		PKc_like	554..823	CDD:304357	70/284 (25%)
		HNOBA	<839..882	CDD:285003
		CYCc	861..1051	CDD:214485
		Guanylate_cyc	888..1076	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900