DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and gcy-1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_496039.1	Gene:	gcy-1 / 191639	WormBaseID:	WBGene00001528	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	327	Identity:	70/327 - (21%)
Similarity:	123/327 - (37%)	Gaps:	66/327 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1041 VKSGAILRRPVCRERWELSNDDVVLLERIGRG-------------------------NFGDVYKA 1080
            |.||....|......|::....::..|:..||                         :|.:.|..
Worm   518 VISGKRAERARINAEWQVPFAKLIESEKQVRGKGASRRSLQSAPSISTGHSGVTTVSDFCENYTM 582

  Fly  1081 KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGS 1145
            .:...::.:..|.....|....|.:|::    :::.||.||.:.||:.:.....:.|.:|...||
Worm   583 MMYEKEMVLTAKYQYTHLTKADKERFVK----MRKLDHENINRFIGLSIDSAHFISVTKLCSRGS 643

  Fly  1146 LLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNC-IHRDLAARNCLVDLEHSVKISDFGMSRE 1209
            |...|.:.:..:.......:.||.|.|:.||..... :|.:|.:..|||:....||::::||...
Worm   644 LQDILSRGNFSMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMDNL 708

  Fly  1210 EEEYIVSDGMKQIPVK----WTAPE----ALNFGKYTSLCDVWSYGIL---------MWEIFSKG 1257
            .||        |.|.|    |.|||    :|:..:.....|::|:.|:         .|:|..:.
Worm   709 VEE--------QTPPKKRLLWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKKEAWDILDRK 765

  Fly  1258 DTPYSGMTNSR------ARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDA 1316
            :.....:.|.:      .|..|.|......|     .:..|:..|||...|.||..:.|.:.:..
Worm   766 EDCEEIVYNVKKGGLFPIRPEIITDIHDVNP-----ALIALVKDCWAEVPEDRPTAENICSQMKG 825

  Fly  1317 LI 1318
            |:
Worm   826 LV 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	63/296 (21%)
		PTKc_Fes_like	1067..1315	CDD:270637	64/296 (22%)
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347
		ANF_receptor	53..432	CDD:279440
		PKc_like	555..821	CDD:304357	61/282 (22%)
		HNOBA	<840..883	CDD:285003
		CYCc	862..1051	CDD:214485
		Guanylate_cyc	889..1077	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900