DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and frk-1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001369901.1	Gene:	frk-1 / 191635	WormBaseID:	WBGene00001487	Length:	390	Species:	Caenorhabditis elegans

Alignment Length:	419	Identity:	145/419 - (34%)
Similarity:	236/419 - (56%)	Gaps:	54/419 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   906 GELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEV 970
            |.::::|:.|.        |.:||:.|                         .|::||::||::.
Worm     2 GTVEKSSNNDA--------SVTDDIRS-------------------------AEYYHGMVPRQDA 33

  Fly   971 VRLLNNDGDFLVRETIRNEESQIVLS--------VCWNGHKHFIVQTTGEGN-FRFEGP-PFASI 1025
            ...|..:||||||:| .....::||:        :|    :||::......| |.||.. ..::|
Worm    34 EGFLKREGDFLVRKT-EQMPGKVVLAMSVRVTDELC----RHFMLNMDPTSNKFYFEHTHQESTI 93

  Fly  1026 QELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL-KSTKLDV 1089
            .|||.....::.|::..|||.:|||:.|..|.:::|.:|..:::|.|.||||:.|:| :..|.:|
Worm    94 SELINWHMTTKTPISAASGAKIRRPMERSPWLINHDSIVANKKLGEGAFGDVFIAELDQGGKQEV 158

  Fly  1090 AVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNS 1154
            ||||.|.....|.:.:|::|.|::::|.|.::|||||:.:.:.|:|||||....||||::|:||.
Worm   159 AVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPNGSLLSHLKKNK 223

  Fly  1155 NGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGM 1219
            ..|.  :::....:||.|:.|||...|||||:||||||:..::.:||||||||..::| |..:.:
Worm   224 VSLI--EKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSDNKDE-IKDETL 285

  Fly  1220 KQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTG-YRMPTPK 1283
            :::|:||.|||.:....||...|:|::|:|:|||:|.|..||.|:|..:.|.:|... |||..|.
Worm   286 EKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIYSDGAEPYPGLTKIQTRAKIVVNDYRMKMPD 350

  Fly  1284 STPEEMYRLML-QCWAADAESRPHFDEIY 1311
            .|...:..::. .||..:.|.|...|.|:
Worm   351 GTHPTVADVVTGTCWQKNPEKRSTMDSIH 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	26/95 (27%)
		TyrKc	1063..1311	CDD:197581	101/250 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/248 (41%)
frk-1	NP_001369901.1	SH2_Fps_family	16..107	CDD:198224	29/120 (24%)
frk-1	NP_001369901.1	TyrKc	131..382	CDD:197581	102/252 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74300
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm14377
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3894
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.950