DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and ZK622.1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_494994.1	Gene:	ZK622.1 / 191366	WormBaseID:	WBGene00022780	Length:	419	Species:	Caenorhabditis elegans

Alignment Length:	405	Identity:	147/405 - (36%)
Similarity:	232/405 - (57%)	Gaps:	29/405 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   942 SLAASISLSTNRPLYEE-EWFHGVLPREEVVRLLNNDGDFLVRET--IRNEESQIVLSVCWNGH- 1002
            ::.||:.....|..::: :|:||:|||.::..||.||||||||.:  :..:.::.||||.|.|.
Worm    13 TVEASLRSDGTRKKHQDMDWYHGLLPRADINTLLENDGDFLVRTSHIVGQDSAKTVLSVKWKGKC 77

  Fly  1003 KHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLE 1067
            .|:.:|...:|:...|...|.|:.:::.......|||:....|:|..|:.::.|||.:|.:.|.:
Worm    78 HHWQLQEKEDGSIVIEERKFESVLDMVTTLRMKRLPVSANCPALLLNPINKQDWELRHDQIKLGK 142

  Fly  1068 RIGRGNFGDVYKAKL--KSTKLDVAVK--------TCRMTLPDEQKRKFLQEGRILKQYDHPNIV 1122
            .:|.|.||.||||..  |..|..||||        :.|..:.|..|     |.||::||.|||:|
Worm   143 MLGEGAFGGVYKAAFYCKGEKRMVAVKVNKGNEKISTRAMIEDVCK-----EARIMRQYQHPNVV 202

  Fly  1123 KLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLA 1187
            ...|:||:|:|||:||||...|:|.::|:...|.::.|.::....||:.|:.||....|||||:|
Worm   203 CFFGVCVEKEPIMLVMELASQGALDSFLKNEKNNVSLRDKLKYSFDASKGLEYLHQHGCIHRDVA 267

  Fly  1188 ARNCLVDLEHSVKISDFGMSRE----EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGI 1248
            |||.|:. ::.|||:|||:|::    ..:|.:.|...::|::|.|||.:....||...||:|:||
Worm   268 ARNFLMH-KNVVKITDFGLSKQLSDLAHKYKLKDIQAKLPIRWLAPEVIVTATYTFKSDVYSFGI 331

  Fly  1249 LMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLML-QCWAADAESRPHFDEI-- 1310
            |:||||..|..||.||..:..::::..||||..|...|..:..:|: |||..:.|.|.:.:||
Worm   332 LLWEIFMDGAIPYPGMKLAEVKQKVKNGYRMDAPDRMPAFVRNIMISQCWPQNPEDRGNMNEIRL 396

  Fly  1311 --YNVVDALILRLDN 1323
              .:|:|..:...:|
Worm   397 AMESVLDGKVAASNN 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/89 (34%)
		TyrKc	1063..1311	CDD:197581	103/266 (39%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/266 (39%)
ZK622.1	NP_494994.1	SH2_Fps_family	25..114	CDD:198224	29/88 (33%)
		TyrKc	138..398	CDD:197581	103/265 (39%)
		PTKc	142..399	CDD:270623	102/262 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I7354
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810