DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Y52D5A.2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_500813.3	Gene:	Y52D5A.2 / 190185	WormBaseID:	WBGene00021793	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	135/461 - (29%)
Similarity:	213/461 - (46%)	Gaps:	92/461 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   898 DHPFESSSG-----ELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLY- 956
            |...|.:.|     :::.|..|.||...::.|..:.:|             ::|::|| |..::
Worm    12 DFTLEYARGSDVPSDIEPNDKRPIDPRADKLDMGNKNV-------------SSSMTLS-NTSMHD 62

  Fly   957 --EEEW----------FHGVLPREEVVRLLNNDGDFLVRETIRNEESQ-IVLSVCWNGHKHFIVQ 1008
              |||:          :||||...||.::|..|..:|||..|.....: :.:||.|. :|.|..|
Worm    63 DPEEEYIRNHLINLHVYHGVLFGSEVEKILQWDRSYLVRRAITEPMKKFLCISVNWK-NKVFHYQ 126

  Fly  1009 TTGEGNFRFEG----------PPFASIQELIMHQ----YHSELPVTVKSGAILRRPVCRERWELS 1059
            .    :|..:|          ||....:.|.|.|    :....|..:        |:.|....|.
Worm   127 L----DFNDDGWSCTKLYEKFPPMPKRRFLHMSQLLEVWSQATPFLI--------PMPRRPNVLF 179

  Fly  1060 NDDVVLLERIGRGNFGDVYKAKLK---STK--LDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHP 1119
            :..|:|.:::|.|.||.|:|.|.:   ||.  |:||||........:|.::|..|.:|:....|.
Worm   180 HSTVLLEKKLGSGAFGVVFKGKYQAFGSTNPPLEVAVKRIIGNSNRKQIQEFCNEAQIMSMLQHD 244

  Fly  1120 NIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHR 1184
            |:|...|....::|||:|||       |.||| .:..:..||......:.|:||::|.||..|||
Worm   245 NMVAFRGFASLEEPIMVVME-------LKYLR-TTRDIPKRQIFWFAMNVASGMKHLSSKGIIHR 301

  Fly  1185 DLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGIL 1249
            |||||||||..:...||||||:|.:..|..|:: :.:.|::|.|||:.|.|.:....||||||:|
Worm   302 DLAARNCLVTQDLKAKISDFGLSCQGTEVTVTN-LCRAPLRWMAPESFNSGTFNEKTDVWSYGVL 365

  Fly  1250 MWEIFSKGD-TPYSGMTNSRAR---------ERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESR 1304
            :.|:.::.: .|...|:...|:         .||..|        .|:|:..|:..|...:.:.|
Worm   366 LTELMTRCEHDPLYPMSLKDAKAWIASESFPHRIVNG--------DPKELMSLVDACCDKNVKDR 422

  Fly  1305 PHFDEI 1310
            ..|:.:
Worm   423 IKFNTV 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/113 (25%)
		TyrKc	1063..1311	CDD:197581	90/263 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	88/259 (34%)
Y52D5A.2	NP_500813.3	SH2	79..163	CDD:214585	25/88 (28%)
		TyrKc	183..432	CDD:197581	90/263 (34%)
		PTKc	187..432	CDD:270623	88/259 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870