Protein Alignment FER and Y52D5A.2

DIOPT Version :10

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_500813.3
• Gene: Y52D5A.2 / 190185
• WormBaseID: WBGene00021793
• Length: 544
• Species: Caenorhabditis elegans
• Alignment Length: 461
• Identity: 135/461 - (29%)
• Similarity: 213/461 - (46%)
• Gaps: 92/461 - (19%)

  Fly   898 DHPFESSSG-----ELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLY- 956
            |...|.:.|     :::.|..|.||...::.|..:.:|             ::|::|| |..::
 Worm    12 DFTLEYARGSDVPSDIEPNDKRPIDPRADKLDMGNKNV-------------SSSMTLS-NTSMHD 62

  Fly   957 --EEEW----------FHGVLPREEVVRLLNNDGDFLVRETIRNEESQ-IVLSVCWNGHKHFIVQ 1008
              |||:          :||||...||.::|..|..:|||..|.....: :.:||.|. :|.|..|
 Worm    63 DPEEEYIRNHLINLHVYHGVLFGSEVEKILQWDRSYLVRRAITEPMKKFLCISVNWK-NKVFHYQ 126

  Fly  1009 TTGEGNFRFEG----------PPFASIQELIMHQ----YHSELPVTVKSGAILRRPVCRERWELS 1059
            .    :|..:|          ||....:.|.|.|    :....|..:        |:.|....|.
 Worm   127 L----DFNDDGWSCTKLYEKFPPMPKRRFLHMSQLLEVWSQATPFLI--------PMPRRPNVLF 179

  Fly  1060 NDDVVLLERIGRGNFGDVYKAKLK---STK--LDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHP 1119
            :..|:|.:::|.|.||.|:|.|.:   ||.  |:||||........:|.::|..|.:|:....|.
 Worm   180 HSTVLLEKKLGSGAFGVVFKGKYQAFGSTNPPLEVAVKRIIGNSNRKQIQEFCNEAQIMSMLQHD 244

  Fly  1120 NIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHR 1184
            |:|...|....::|||:|||       |.||| .:..:..||......:.|:||::|.||..|||
 Worm   245 NMVAFRGFASLEEPIMVVME-------LKYLR-TTRDIPKRQIFWFAMNVASGMKHLSSKGIIHR 301

  Fly  1185 DLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGIL 1249
            |||||||||..:...||||||:|.:..|..|:: :.:.|::|.|||:.|.|.:....||||||:|
 Worm   302 DLAARNCLVTQDLKAKISDFGLSCQGTEVTVTN-LCRAPLRWMAPESFNSGTFNEKTDVWSYGVL 365

  Fly  1250 MWEIFSKGD-TPYSGMTNSRAR---------ERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESR 1304
            :.|:.::.: .|...|:...|:         .||..|        .|:|:..|:..|...:.:.|
 Worm   366 LTELMTRCEHDPLYPMSLKDAKAWIASESFPHRIVNG--------DPKELMSLVDACCDKNVKDR 422

  Fly  1305 PHFDEI 1310
            ..|:.:
 Worm   423 IKFNTV 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/113 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	88/259 (34%)
Y52D5A.2	NP_500813.3	SH2	79..163	CDD:214585	25/88 (28%)
		TyrKc	183..432	CDD:197581	90/263 (34%)