DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Y47G6A.5

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_491175.2	Gene:	Y47G6A.5 / 189992	WormBaseID:	WBGene00021635	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	668	Identity:	171/668 - (25%)
Similarity:	280/668 - (41%)	Gaps:	161/668 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   744 HHHSSGSDCPTNSSSSSSNNNNNNKNTSS----NSNHSASQSTIITSTITTTITTTTTTTPSKEN 804
            |.||.      :...:..:..|||:...|    :....:||...:...:..  :|.:...|:|.
Worm     3 HKHSH------HEKKNKKDERNNNREYRSAVLLDDGSFSSQELALRPVMPE--STPSVAVPAKP- 58

  Fly   805 SRLKFKVPKIQKKSKAIRNT----------FRSKLLNFQLKRSKPCKQCTKRRRIHPS----KSV 855
                   |.::..::::.:|          ..|.|:      ..|....:.....|||    |||
Worm    59 -------PPLRPSTQSVSSTDPRPPIPPRRSESNLV------PPPIPHHSGNISRHPSATSTKSV 110

  Fly   856 FDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDH-PFESSSGELDEN----SDRD 915
                       |.|::          ...:||..:     |..| ..:.|..|.:|.    .:|.
Worm   111 -----------PNGAS----------FSPRPVSKT-----HSHHGSAKCSHSEPEEKMLIVENRF 149

  Fly   916 IDNDEEEEDSASDDVL-----SMKDHCYCVPSLAASISLSTNRPL-------------YEEEWFH 962
            :....:|......|||     |.::..|..         |.:|..             |.|.||.
Worm   150 LAQTPKEMSVEEGDVLYLIEQSNREWWYVA---------SKSRQFKGFVPKSHVVYAEYREPWFA 205

  Fly   963 G----VLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKH----FIV--QTTGEG---- 1013
            |    :|..:.|::.....|.||:||   |.::...:.|..:.|..    :|:  :...||
Worm   206 GNISSILAEQRVMQPQLPIGSFLIRE---NSKTDTFVLVVRSSHNESPQAYIIYRRPNQEGFEIR 267

  Fly  1014 -NFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRR--PVCRERWE--------LSNDDVVLLE 1067
             |.|.....|.|:.:|:.|....::|..::....|.:  |...|:.|        ::..:|..::
Worm   268 DNHRPAVIHFGSLHQLVNHYSCEKVPGEIQICTKLTKAAPPLPEQTEYMAMKKIHVNRSEVRRVK 332

  Fly  1068 RIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKR----KFLQEGRILKQYDHPNIVKLIGIC 1128
            .||||.||:||.||.|.  :|||||:.:   ||..::    :||:|.:.|.:..|.|::.|:.:|
Worm   333 EIGRGQFGEVYLAKWKG--VDVAVKSLK---PDHSEQLANTQFLEEAKTLTKLSHQNVIHLLAVC 392

  Fly  1129 VQKQPIMIVMELVLGGSLLTYLRKNSNGL---------TTRQQM----GMCRDAAAGMRYLESKN 1180
            ...:|.:|:.|.:..||||.:|:|.:..|         |.|:.:    .:....|:||.||.:..
Worm   393 DTDKPYLIITEFMTNGSLLAWLQKLTKTLPPIPLMSEETGRKNVLIGASISAQVASGMDYLSANK 457

  Fly  1181 CIHRDLAARNCLVDLEHS-----VKISDFGMSRE----EEEYIV-SDGMKQIPVKWTAPEALNFG 1235
            .:||||||||.||....|     ||::|||::|:    :|.|:: :|.|  :|.||.|||..:..
Worm   458 IVHRDLAARNVLVGTVSSNGVPLVKVADFGLARKTDVGDENYVMKTDNM--LPWKWMAPECFDEQ 520

  Fly  1236 KYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQ-CWAA 1299
            .:.:..||||||||:|||.:.|.|||.|.......|.:..||.:|.|:..|:.:|....: |...
Worm   521 IFNTKTDVWSYGILLWEIGTLGKTPYRGWDYEGTLEHLSRGYVLPRPELVPDYVYEDAFKICVHL 585

  Fly  1300 DAESRPHFDEIYNVVDAL 1317
            |...||.||.::...|.:
Worm   586 DPRRRPTFDRLFKYFDEI 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/113 (22%)
		TyrKc	1063..1311	CDD:197581	100/275 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	99/275 (36%)
Y47G6A.5	NP_491175.2	SH3	151..194	CDD:302595	8/51 (16%)
		SH2	201..305	CDD:301589	25/106 (24%)
		TyrKc	328..600	CDD:197581	100/278 (36%)
		PTKc	332..601	CDD:270623	99/275 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910