DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Y43C5B.2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_501907.1	Gene:	Y43C5B.2 / 189849	WormBaseID:	WBGene00012785	Length:	245	Species:	Caenorhabditis elegans

Alignment Length:	225	Identity:	69/225 - (30%)
Similarity:	121/225 - (53%)	Gaps:	29/225 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   945 ASISLSTNRPLYEEE-WFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQIVLSVCWNGH---- 1002
            ||.:.|..||..|:| ::||.||||:|..:|.|:|||::|  |.........:|||.   |
Worm     2 ASGTASMQRPSIEKEPYYHGFLPREDVKTVLKNNGDFVIRISEPQAGSPRSNILSVM---HCVPP 63

  Fly  1003 -----KHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDD 1062
                 ||::::|.|:..| .|...|.||.|::  ::|.....:|:....|.:.:.|:.|||.:|:
Worm    64 MEEEIKHYVIKTKGDKIF-IEKVSFLSIPEMV--EWHLTKKESVQKDVFLIKAISRQAWELDHDN 125

  Fly  1063 VVLLERIGRGNFGDVYKAKLKSTK----LDVAVKTCRMT-LPDEQKRKFLQEGRILKQYDHPNIV 1122
            :..|:::|.|.||:|....:|..|    :.||:|..::: |..||.::|:.|.|:::...||::|
Worm   126 IEPLKKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKEQIKEFMGEARVMRSLSHPHVV 190

  Fly  1123 KLIGICVQKQPIMIVMELVLGGSLLTYLRK 1152
            :..|:..::      :.:.|..||..:|.|
Worm   191 RFYGVPRRR------VNVALCRSLNEFLAK 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	33/97 (34%)
		TyrKc	1063..1311	CDD:197581	26/95 (27%)
		PTKc_Fes_like	1067..1315	CDD:270637	25/91 (27%)
Y43C5B.2	NP_501907.1	SH2_Fps_family	11..104	CDD:198224	32/98 (33%)
Y43C5B.2	NP_501907.1	PKc_like	130..>195	CDD:304357	19/64 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810